Background: During the 2014-2015 US influenza season, 320 cases of non-mumps parotitis (NMP) among residents of 21 states were reported to the Centers for Disease Control and Prevention (CDC). We conducted an epidemiologic and laboratory investigation to determine viral etiologies and clinical features of NMP during this unusually large occurrence. Methods: NMP was defined as acute parotitis or other salivary gland swelling of >2 days duration in a person with a mumps- negative laboratory result. Using a standardized questionnaire, we collected demographic and clinical information. Buccal samples were tested at the CDC for selected viruses, including mumps, influenza, human parainfluenza viruses (HPIVs) 1-4, adenoviruses, cytomegalovirus, Epstein-Barr virus (EBV), herpes simplex viruses (HSVs) 1 and 2, and human herpes viruses (HHVs) 6A and 6B. Results: Among the 320 patients, 65% were male, median age was 14.5 years (range, 0-90), and 67% reported unilateral parotitis. Commonly reported symptoms included sore throat (55%) and fever (48%). Viruses were detected in 210 (71%) of 294 NMP patients with adequate samples for testing, ≥2 viruses were detected in 37 samples, and 248 total virus detections were made among all samples. These included 156 influenza A(H3N2), 42 HHV6B, 32 EBV, 8 HPIV2, 2 HPIV3, 3 adenovirus, 4 HSV-1, and 1 HSV-2. Influenza A(H3N2), HHV6B, and EBV were the most frequently codetected viruses. Conclusions: Our findings suggest that, in addition to mumps, clinicians should consider respiratory viral (influenza) and herpes viral etiologies for parotitis, particularly among patients without epidemiologic links to mumps cases or outbreaks.
Background: During the 2014-2015 US influenza season, 320 cases of non-mumps parotitis (NMP) among residents of 21 states were reported to the Centers for Disease Control and Prevention (CDC). We conducted an epidemiologic and laboratory investigation to determine viral etiologies and clinical features of NMP during this unusually large occurrence. Methods:NMP was defined as acute parotitis or other salivary gland swelling of >2 days duration in a person with a mumps- negative laboratory result. Using a standardized questionnaire, we collected demographic and clinical information. Buccal samples were tested at the CDC for selected viruses, including mumps, influenza, humanparainfluenza viruses (HPIVs) 1-4, adenoviruses, cytomegalovirus, Epstein-Barr virus (EBV), herpes simplex viruses (HSVs) 1 and 2, and human herpes viruses (HHVs) 6A and 6B. Results: Among the 320 patients, 65% were male, median age was 14.5 years (range, 0-90), and 67% reported unilateral parotitis. Commonly reported symptoms included sore throat (55%) and fever (48%). Viruses were detected in 210 (71%) of 294 NMPpatients with adequate samples for testing, ≥2 viruses were detected in 37 samples, and 248 total virus detections were made among all samples. These included 156 influenza A(H3N2), 42 HHV6B, 32 EBV, 8 HPIV2, 2 HPIV3, 3 adenovirus, 4HSV-1, and 1 HSV-2. Influenza A(H3N2), HHV6B, and EBV were the most frequently codetected viruses. Conclusions: Our findings suggest that, in addition to mumps, clinicians should consider respiratory viral (influenza) and herpes viral etiologies for parotitis, particularly among patients without epidemiologic links to mumps cases or outbreaks.
Authors: Jennifer S Rota; Jennifer B Rosen; Margaret K Doll; Rebecca J McNall; Marcia McGrew; Nobia Williams; Elena N Lopareva; Albert E Barskey; Amado Punsalang; Paul A Rota; William R Oleszko; Carole J Hickman; Christopher M Zimmerman; William J Bellini Journal: Clin Vaccine Immunol Date: 2013-01-16
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Authors: Aina Scatti-Regàs; Marta Carmen Aguilar-Ferrer; Andrés Antón-Pagarolas; Xavier Martínez-Gómez; Sebastià González-Peris Journal: An Pediatr (Engl Ed) Date: 2020-07-19
Authors: Aina Scatti-Regàs; Marta Carmen Aguilar-Ferrer; Andrés Antón-Pagarolas; Xavier Martínez-Gómez; Sebastià González-Peris Journal: An Pediatr (Engl Ed) Date: 2019-12-26
Authors: Shirlee Wohl; Hayden C Metsky; Stephen F Schaffner; Anne Piantadosi; Meagan Burns; Joseph A Lewnard; Bridget Chak; Lydia A Krasilnikova; Katherine J Siddle; Christian B Matranga; Bettina Bankamp; Scott Hennigan; Brandon Sabina; Elizabeth H Byrne; Rebecca J McNall; Rickey R Shah; James Qu; Daniel J Park; Soheyla Gharib; Susan Fitzgerald; Paul Barreira; Stephen Fleming; Susan Lett; Paul A Rota; Lawrence C Madoff; Nathan L Yozwiak; Bronwyn L MacInnis; Sandra Smole; Yonatan H Grad; Pardis C Sabeti Journal: PLoS Biol Date: 2020-02-11 Impact factor: 8.029