Literature DB >> 23933872

Designing pharmaceutical trials for sarcopenia in frail older adults: EU/US Task Force recommendations.

B Vellas1, M Pahor, T Manini, D Rooks, J M Guralnik, J Morley, S Studenski, W Evans, C Asbrand, R Fariello, S Pereira, Y Rolland, G Abellan van Kan, M Cesari, Wm C Chumlea, R Fielding.   

Abstract

An international task force of academic and industry leaders in sarcopenia research met on December 5, 2012 in Orlando, Florida to develop guidelines for designing and executing randomized clinical trials of sarcopenia treatments. The Task Force reviewed results from previous trials in related disease areas to extract lessons relevant to future sarcopenia trials, including practical issues regarding the design and conduct of trials in elderly populations, the definition of appropriate target populations, and the selection of screening tools, outcome measures, and biomarkers. They discussed regulatory issues, the challenges posed by trials of different types of interventions, and the need for standardization and harmonization. The Task Force concluded with recommendations for advancing the field toward better clinical trials.

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Year:  2013        PMID： 23933872      PMCID： PMC4077187          DOI： 10.1007/s12603-013-0362-7

Source DB:  PubMed          Journal:  J Nutr Health Aging        ISSN： 1279-7707            Impact factor:   4.075


  50 in total

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2.  Physiological and functional responses to low-moderate versus high-intensity progressive resistance training in frail elders.

Authors:  Olivier Seynnes; Maria A Fiatarone Singh; Olivier Hue; Pierre Pras; Patrick Legros; Pierre L Bernard
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2004-05       Impact factor: 6.053

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Review 4.  Selective androgen receptor modulators in drug discovery: medicinal chemistry and therapeutic potential.

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5.  Study of differences in peripheral muscle strength of lean versus obese women: an allometric approach.

Authors:  M Hulens; G Vansant; R Lysens; A L Claessens; E Muls; S Brumagne
Journal:  Int J Obes Relat Metab Disord       Date:  2001-05

6.  Meaningful change and responsiveness in common physical performance measures in older adults.

Authors:  Subashan Perera; Samir H Mody; Richard C Woodman; Stephanie A Studenski
Journal:  J Am Geriatr Soc       Date:  2006-05       Impact factor: 5.562

7.  Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adults.

Authors:  David J Kosek; Jeong-Su Kim; John K Petrella; James M Cross; Marcas M Bamman
Journal:  J Appl Physiol (1985)       Date:  2006-04-13

8.  Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the Arthritis, Diet, and Activity Promotion Trial.

Authors:  Stephen P Messier; Richard F Loeser; Gary D Miller; Timothy M Morgan; W Jack Rejeski; Mary Ann Sevick; Walter H Ettinger; Marco Pahor; Jeff D Williamson
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9.  Age-related declines in anaerobic muscular performance: weightlifting and powerlifting.

Authors:  Maria M Anton; Waneen W Spirduso; Hirofumi Tanaka
Journal:  Med Sci Sports Exerc       Date:  2004-01       Impact factor: 5.411

10.  Reliability and sensitivity to change assessed for a summary measure of lower body function: results from the Women's Health and Aging Study.

Authors:  Glenn V Ostir; Stefano Volpato; Linda P Fried; Paulo Chaves; Jack M Guralnik
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  18 in total

1.  The Road Ahead to Cure Alzheimer's Disease: Development of Biological Markers and Neuroimaging Methods for Prevention Trials Across all Stages and Target Populations.

Authors:  E Cavedo; S Lista; Z Khachaturian; P Aisen; P Amouyel; K Herholz; C R Jack; R Sperling; J Cummings; K Blennow; S O'Bryant; G B Frisoni; A Khachaturian; M Kivipelto; W Klunk; K Broich; S Andrieu; M Thiebaut de Schotten; J-F Mangin; A A Lammertsma; K Johnson; S Teipel; A Drzezga; A Bokde; O Colliot; H Bakardjian; H Zetterberg; B Dubois; B Vellas; L S Schneider; H Hampel
Journal:  J Prev Alzheimers Dis       Date:  2014-12

Review 2.  Muscle quality in aging: a multi-dimensional approach to muscle functioning with applications for treatment.

Authors:  Maren S Fragala; Anne M Kenny; George A Kuchel
Journal:  Sports Med       Date:  2015-05       Impact factor: 11.136

3.  Comparative performance of current definitions of sarcopenia against the prospective incidence of falls among community-dwelling seniors age 65 and older.

Authors:  H A Bischoff-Ferrari; J E Orav; J A Kanis; R Rizzoli; M Schlögl; H B Staehelin; W C Willett; B Dawson-Hughes
Journal:  Osteoporos Int       Date:  2015-06-12       Impact factor: 4.507

4.  Community-dwelling female fallers have lower muscle density in their lower legs than non-fallers: evidence from the Saskatoon Canadian Multicentre Osteoporosis Study (CaMos) cohort.

Authors:  A W Frank; J P Farthing; P D Chilibeck; C M Arnold; W P Olszynski; S A Kontulainen
Journal:  J Nutr Health Aging       Date:  2015-01       Impact factor: 4.075

5.  A pilot study of the SARC-F scale on screening sarcopenia and physical disability in the Chinese older people.

Authors:  L Cao; S Chen; C Zou; X Ding; L Gao; Z Liao; G Liu; T K Malmstrom; J E Morley; J H Flaherty; Y An; B Dong
Journal:  J Nutr Health Aging       Date:  2014-03       Impact factor: 4.075

6.  PHARMACOLOGICAL INTERVENTIONS IN FRAILTY AND SARCOPENIA: REPORT BY THE INTERNATIONAL CONFERENCE ON FRAILTY AND SARCOPENIA RESEARCH TASK FORCE.

Authors:  M Cesari; R Fielding; O Bénichou; R Bernabei; S Bhasin; J M Guralnik; A Jette; F Landi; M Pahor; L Rodriguez-Manas; Y Rolland; R Roubenoff; A J Sinclair; S Studenski; T Travison; B Vellas
Journal:  J Frailty Aging       Date:  2015

7.  Representation of older patients in clinical trials for drug approval in Japan.

Authors:  Y Asahina; H Sugano; E Sugiyama; Y Uyama
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8.  Intramuscular fat and inflammation differ in older adults: the impact of frailty and inactivity.

Authors:  O Addison; M J Drummond; P C LaStayo; L E Dibble; A R Wende; D A McClain; R L Marcus
Journal:  J Nutr Health Aging       Date:  2014-05       Impact factor: 4.075

9.  Skeletal muscle extracellular matrix remodeling with worsening glycemic control in nonhuman primates.

Authors:  Alistaire D Ruggiero; Ashley Davis; Chrissy Sherrill; Brian Westwood; Gregory A Hawkins; Nicholette D Palmer; Jeff W Chou; Tony Reeves; Laura A Cox; Kylie Kavanagh
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2020-11-18       Impact factor: 3.619

Review 10.  Screening Tools for Sarcopenia.

Authors:  Hiroki Nishikawa; Akira Asai; Shinya Fukunishi; Toshihisa Takeuchi; Masahiro Goto; Takeshi Ogura; Shiro Nakamura; Kazuki Kakimoto; Takako Miyazaki; Shuhei Nishiguchi; Kazuhide Higuchi
Journal:  In Vivo       Date:  2021 Nov-Dec       Impact factor: 2.155
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