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Literature DB >> 23932780

The little elongation complex functions at initiation and elongation phases of snRNA gene transcription.

Deqing Hu¹, Edwin R Smith, Alexander S Garruss, Nima Mohaghegh, Joseph M Varberg, Chengqi Lin, Jessica Jackson, Xin Gao, Anita Saraf, Laurence Florens, Michael P Washburn, Joel C Eissenberg, Ali Shilatifard.

Abstract

The small nuclear RNA (snRNA) genes have been widely used as a model system for understanding transcriptional regulation due to the unique aspects of their promoter structure, selectivity for either RNA polymerase (Pol) II or III, and because of their unique mechanism of termination that is tightly linked with the promoter. Recently, we identified the little elongation complex (LEC) in Drosophila that is required for the expression of Pol II-transcribed snRNA genes. Here, using Drosophila and mammalian systems, we provide genetic and molecular evidence that LEC functions in at least two phases of snRNA transcription: an initiation step requiring the ICE1 subunit, and an elongation step requiring ELL.

Entities: CellLine Chemical Disease Gene Species

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Year: 2013 PMID： 23932780 PMCID： PMC4104523 DOI： 10.1016/j.molcel.2013.07.003

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

49 in total

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Journal: J Biol Chem Date: 2001-06-04 Impact factor: 5.157

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Journal: Science Date: 1987-12-18 Impact factor: 47.728

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Authors: Bijan Sobhian; Nadine Laguette; Ahmad Yatim; Mirai Nakamura; Yves Levy; Rosemary Kiernan; Monsef Benkirane
Journal: Mol Cell Date: 2010-05-14 Impact factor: 17.970

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Journal: Mol Biol Cell Date: 2003-04 Impact factor: 4.138

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Journal: Mol Cell Biol Date: 1985-09 Impact factor: 4.272

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Journal: Cell Date: 1986-10-24 Impact factor: 41.582

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Journal: Methods Enzymol Date: 1983 Impact factor: 1.600

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Authors: Joanne E Medlin; Patricia Uguen; Alice Taylor; David L Bentley; Shona Murphy
Journal: EMBO J Date: 2003-02-17 Impact factor: 11.598

9. dELL is an essential RNA polymerase II elongation factor with a general role in development.

Authors: Joel C Eissenberg; Jiyan Ma; Mark A Gerber; Alan Christensen; James A Kennison; Ali Shilatifard
Journal: Proc Natl Acad Sci U S A Date: 2002-07-02 Impact factor: 11.205

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Authors: Erica Y Jacobs; Ikuo Ogiwara; Alan M Weiner
Journal: Mol Cell Biol Date: 2004-01 Impact factor: 4.272

28 in total

1. Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification.

Authors: Deqing Hu; Xin Gao; Kaixiang Cao; Marc A Morgan; Gloria Mas; Edwin R Smith; Andrew G Volk; Elizabeth T Bartom; John D Crispino; Luciano Di Croce; Ali Shilatifard
Journal: Mol Cell Date: 2017-02-02 Impact factor: 17.970

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Authors: Sylvain Egloff; Cécilia Studniarek; Tamás Kiss
Journal: Transcription Date: 2017-10-04

Review 3. Cajal body function in genome organization and transcriptome diversity.

Authors: Iain A Sawyer; David Sturgill; Myong-Hee Sung; Gordon L Hager; Miroslav Dundr
Journal: Bioessays Date: 2016-10-21 Impact factor: 4.345

4. MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex.

Authors: Hidehisa Takahashi; Ichigaku Takigawa; Masashi Watanabe; Delnur Anwar; Mio Shibata; Chieri Tomomori-Sato; Shigeo Sato; Amol Ranjan; Chris W Seidel; Tadasuke Tsukiyama; Wataru Mizushima; Masayasu Hayashi; Yasuyuki Ohkawa; Joan W Conaway; Ronald C Conaway; Shigetsugu Hatakeyama
Journal: Nat Commun Date: 2015-01-09 Impact factor: 14.919

5. Mediator Is Essential for Small Nuclear and Nucleolar RNA Transcription in Yeast.

Authors: Jason P Tourigny; Moustafa M Saleh; Kenny Schumacher; Didier Devys; Gabriel E Zentner
Journal: Mol Cell Biol Date: 2018-11-28 Impact factor: 4.272

6. Selective expression of the transcription elongation factor ELL3 in B cells prior to ELL2 drives proliferation and survival.

Authors: Lou-Ella M M Alexander; January Watters; Jessica A Reusch; Michelle Maurin; Brook S Nepon-Sixt; Katerina Vrzalikova; Mark G Alexandrow; Paul G Murray; Kenneth L Wright
Journal: Mol Immunol Date: 2017-08-31 Impact factor: 4.407

7. Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced Cancer Therapy.

Authors: Kaiwei Liang; Edwin R Smith; Yuki Aoi; Kristen L Stoltz; Hiroaki Katagi; Ashley R Woodfin; Emily J Rendleman; Stacy A Marshall; David C Murray; Lu Wang; Patrick A Ozark; Rama K Mishra; Rintaro Hashizume; Gary E Schiltz; Ali Shilatifard
Journal: Cell Date: 2018-10-18 Impact factor: 41.582