Literature DB >> 23929104

Methods of testing pharmacological drugs effects on aging and life span in mice.

Vladimir N Anisimov1, Irina G Popovich, Mark A Zabezhinski.   

Abstract

The methodology of testing antiaging drugs in laboratory mice is presented. It is based on more than 40-year-long authors' experience in the field and includes the selection of mouse strain, sex, age at start of treatment, housing conditions, design of the long-term study, some noninvasive methods of assessment of biomarkers of aging, life-span parameters, pathology examination, and statistical treatment of the results.

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Year:  2013        PMID: 23929104     DOI: 10.1007/978-1-62703-556-9_12

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN: 1064-3745


  5 in total

1.  Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin.

Authors:  Irina G Popovich; Vladimir N Anisimov; Mark A Zabezhinski; Anna V Semenchenko; Margarita L Tyndyk; Maria N Yurova; Mikhail V Blagosklonny
Journal:  Cancer Biol Ther       Date:  2014-02-20       Impact factor: 4.742

2.  In mice transgenic for IGF1 under keratin-14 promoter, lifespan is decreased and the rates of aging and thymus involution are accelerated.

Authors:  Vladimir N Anisimov; Irina F Labunets; Irina G Popovich; Margarita L Tyndyk; Maria N Yurova; Alexey G Golubev
Journal:  Aging (Albany NY)       Date:  2019-04-13       Impact factor: 5.682

3.  Aging delay: of mice and men.

Authors:  Vladimir Anisimov
Journal:  Acta Biomed       Date:  2021-01-28

4.  Polyphenolic drug composition based on benzenepolycarboxylic acids (BP-C3) increases life span and inhibits spontaneous tumorigenesis in female SHR mice.

Authors:  Vladimir N Anisimov; Irina G Popovich; Mark A Zabezhinski; Maria N Yurova; Margarita L Tyndyk; Ivan V Anikin; Peter A Egormin; Irina A Baldueva; Elena I Fedoros; Sergey E Pigarev; Andrey V Panchenko
Journal:  Aging (Albany NY)       Date:  2016-08-28       Impact factor: 5.682

5.  It is necessary to establish an International Agency for Research on Aging.

Authors:  Vladimir N Anisimov; Alexandre V Sidorenko
Journal:  Aging (Albany NY)       Date:  2018-05-12       Impact factor: 5.682

  5 in total

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