Literature DB >> 23928945

Scleral fixation of dexamethasone intravitreal implant (OZURDEX®) in a case of angle-supported lens implantation.

Carlos Mateo1, Micol Alkabes, Anniken Burés-Jelstrup.   

Abstract

OZURDEX(®) is a biodegradable drug delivery system which has been reported to be an effective treatment in cases of macular edema. However, migration of the implant into the anterior chamber with elevation of intraocular pressure and corneal decompensation might occur in some cases. We report a case of an 80-year-old male who underwent intravitreal scleral fixation of OZURDEX(®) due to postoperative macular edema secondary to complicated cataract surgery. He had a previous angle-supported lens implantation with superior Nd:YAG laser iridotomy. During surgery, the dexamethasone implant was introduced into the vitreous cavity and sutured to the sclera using a 10-0 non-absorbable polypropylene suture to prevent the risk of anterior complications in case of migration into the anterior chamber. After 6 months of follow-up, the macular edema had disappeared completely, the drug delivery system was not observed in the posterior segment and best-corrected visual acuity improved from 20/125 to 20/40 (Snellen equivalent). Neither anterior nor posterior segment complications were reported during the follow-up period. Intravitreal scleral fixation of the OZURDEX(®) to the pars plana could be recommended as an alternative technique to avoid anterior migration of the device in a patient with an anterior chamber intraocular lens, which may lead to corneal decompensation and increased intraocular pressure.

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Year:  2013        PMID: 23928945     DOI: 10.1007/s10792-013-9841-4

Source DB:  PubMed          Journal:  Int Ophthalmol        ISSN: 0165-5701            Impact factor:   2.031


  7 in total

1.  Anterior chamber migration of dexametasone intravitreal implant (Ozurdex®).

Authors:  Diamar Pardo-López; Ester Francés-Muñoz; Roberto Gallego-Pinazo; Manuel Díaz-Llopis
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2011-08-23       Impact factor: 3.117

2.  Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema.

Authors:  Baruch D Kuppermann; Mark S Blumenkranz; Julia A Haller; George A Williams; David V Weinberg; Connie Chou; Scott M Whitcup
Journal:  Arch Ophthalmol       Date:  2007-03

3.  Repositioning of dexamethasone intravitreal implant (Ozurdex) migrated into the anterior chamber.

Authors:  José I Vela; Jaume Crespí; David Andreu
Journal:  Int Ophthalmol       Date:  2012-07-05       Impact factor: 2.031

4.  Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion.

Authors:  Julia A Haller; Francesco Bandello; Rubens Belfort; Mark S Blumenkranz; Mark Gillies; Jeffrey Heier; Anat Loewenstein; Young-Hee Yoon; Marie-Louise Jacques; Jenny Jiao; Xiao-Yan Li; Scott M Whitcup
Journal:  Ophthalmology       Date:  2010-04-24       Impact factor: 12.079

5.  Dexamethasone posterior-segment drug delivery system in the treatment of macular edema resulting from uveitis or Irvine-Gass syndrome.

Authors:  George A Williams; Julia A Haller; Baruch D Kuppermann; Mark S Blumenkranz; David V Weinberg; Connie Chou; Scott M Whitcup
Journal:  Am J Ophthalmol       Date:  2009-03-09       Impact factor: 5.258

6.  Clinical applications of the sustained-release dexamethasone implant for treatment of macular edema.

Authors:  Rocío Herrero-Vanrell; Jose Augusto Cardillo; Baruch D Kuppermann
Journal:  Clin Ophthalmol       Date:  2011-02-01

7.  Wandering Ozurdex(®) implant.

Authors:  Reema Bansal; Pooja Bansal; Pandurang Kulkarni; Vishali Gupta; Aman Sharma; Amod Gupta
Journal:  J Ophthalmic Inflamm Infect       Date:  2011-09-30
  7 in total
  11 in total

1.  New Drugs and New Posterior Delivery Methods in CME.

Authors:  João Rafael de Oliveira Dias; Renata Portella Nunes; Raquel Goldhardt
Journal:  Curr Ophthalmol Rep       Date:  2017-04-07

2.  Anterior migration of dexamethasone implant in a pseudophakic patient with intact posterior capsule.

Authors:  Nilufer Kocak; Taylan Ozturk; Eyyup Karahan; Suleyman Kaynak
Journal:  Indian J Ophthalmol       Date:  2014-11       Impact factor: 1.848

3.  COMBINED VITRECTOMY AND INTRAVITREAL DEXAMETHASONE (OZURDEX) SUSTAINED-RELEASE IMPLANT.

Authors:  Andrew Zheng; Eric K Chin; David R P Almeida; Stephen H Tsang; Vinit B Mahajan
Journal:  Retina       Date:  2016-11       Impact factor: 4.256

4.  Corneal graft failure due to migration of Ozurdex™ implant into the anterior chamber.

Authors:  Haifa A Madi; Stephen J Morgan; Saurabh Ghosh
Journal:  Am J Ophthalmol Case Rep       Date:  2017-09-01

5.  The nomadic Ozurdex®: Anterior migration of the dexamethasone implant and back!

Authors:  Priya Srinivasan; Chaitra Jayadev; Rohit Shetty
Journal:  Oman J Ophthalmol       Date:  2017 May-Aug

6.  Anterior Chamber Migration of Ozurdex Implants.

Authors:  Özcan Kayıkcıoğlu; Suzan Doğruya; Cansu Sarıgül; Hüseyin Mayalı; Emin Kurt
Journal:  Turk J Ophthalmol       Date:  2020-04-29

7.  Anterior chamber migration of a sustained-release dexamethasone intravitreal implant: A case report and review of literature.

Authors:  Parthopratim Dutta Majumder; Amit H Palkar; Nikita Pathare; Jyotirmay Biswas
Journal:  Oman J Ophthalmol       Date:  2019 May-Aug

8.  Modified insertion technique for a sustained-release dexamethasone intravitreal implant (Ozurdex®).

Authors:  Daniel H Lee; Clement K Chan
Journal:  Am J Ophthalmol Case Rep       Date:  2020-04-30

9.  Uneventful Anterior Migration of Intravitreal Ozurdex Implant in a Patient with Iris-Sutured Intraocular Lens and Descemet Stripping Automated Endothelial Keratoplasty.

Authors:  Andleeb Zafar; Ioannis M Aslanides; Vasileios Selimis; Konstantinos I Tsoulnaras; David Tabibian; George D Kymionis
Journal:  Case Rep Ophthalmol       Date:  2018-02-14

10.  Scleral Fixation of the Fluocinolone Acetonide Implant in Eyes with Severe Iris-Lens Diaphragm Disruption and Recalcitrant CME: The Fluocinolone-Loop-Anchoring Technique (FLAT).

Authors:  Tina R Herold; Raffael Liegl; Susanna Koenig; Ahmed Almarzooqi; Siegfried G Priglinger; Armin Wolf
Journal:  Ophthalmol Ther       Date:  2020-02-13
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