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Literature DB >> 23925577

Rapid and efficient synthesis of [11C]ureas via the incorporation of [11C]CO2 into aliphatic and aromatic amines.

Abdul Karim Haji Dheere¹, Nadiya Yusuf, Antony Gee.

Abstract

A rapid urea radiolabelling methodology has been developed. [(11)C]CO2 was activated by 1,8-diazabicycloundec-7-ene (DBU) in the presence of aliphatic and aromatic amines and reacted with Mitsunobu reagents to produce asymmetric (11)C radiolabelled ureas in high radiochemical yields.

Entities: Chemical

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Year: 2013 PMID： 23925577 DOI： 10.1039/c3cc44046j

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

12 in total

Review 1. Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging.

Authors: Victor W Pike
Journal: Curr Med Chem Date: 2016 Impact factor: 4.530

Review 2. (11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals.

Authors: Benjamin H Rotstein; Steven H Liang; Michael S Placzek; Jacob M Hooker; Antony D Gee; Frédéric Dollé; Alan A Wilson; Neil Vasdev
Journal: Chem Soc Rev Date: 2016-08-22 Impact factor: 54.564

Review 3. Chemistry for Positron Emission Tomography: Recent Advances in ¹¹ C-, ¹⁸ F-, ¹³ N-, and ¹⁵ O-Labeling Reactions.

Authors: Xiaoyun Deng; Jian Rong; Lu Wang; Neil Vasdev; Lei Zhang; Lee Josephson; Steven H Liang
Journal: Angew Chem Int Ed Engl Date: 2019-01-14 Impact factor: 15.336

Rapid and efficient synthesis of [11C]ureas via the incorporation of [11C]CO2 into aliphatic and aromatic amines.

Review 1. Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging.

Review 2. (11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals.

Review 3. Chemistry for Positron Emission Tomography: Recent Advances in ¹¹ C-, ¹⁸ F-, ¹³ N-, and ¹⁵ O-Labeling Reactions.

4. "In-loop" [¹¹ C]CO₂ fixation: Prototype and proof of concept.

5. Synthesis of Diverse (11)C-Labeled PET Radiotracers via Direct Incorporation of [(11)C]CO2.

6. From [¹¹C]CO₂ to [¹¹C]amides: a rapid one-pot synthesis via the Mitsunobu reaction.

Review 7. New methodologies for the preparation of carbon-11 labeled radiopharmaceuticals.

8. Instantaneous Conversion of [¹¹ C]CO₂ to [¹¹ C]CO via Fluoride-Activated Disilane Species.

9. Recent progress in [¹¹ C]carbon dioxide ([¹¹ C]CO₂ ) and [¹¹ C]carbon monoxide ([¹¹ C]CO) chemistry.

10. In-loop flow [¹¹ C]CO₂ fixation and radiosynthesis of N,N'-[¹¹ C]dibenzylurea.

Rapid and efficient synthesis of [11C]ureas via the incorporation of [11C]CO2 into aliphatic and aromatic amines.

Review 1. Considerations in the Development of Reversibly Binding PET Radioligands for Brain Imaging.

Review 2. (11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals.

Review 3. Chemistry for Positron Emission Tomography: Recent Advances in 11 C-, 18 F-, 13 N-, and 15 O-Labeling Reactions.

4. "In-loop" [11 C]CO2 fixation: Prototype and proof of concept.

5. Synthesis of Diverse (11)C-Labeled PET Radiotracers via Direct Incorporation of [(11)C]CO2.

6. From [11C]CO2 to [11C]amides: a rapid one-pot synthesis via the Mitsunobu reaction.

Review 7. New methodologies for the preparation of carbon-11 labeled radiopharmaceuticals.

8. Instantaneous Conversion of [11 C]CO2 to [11 C]CO via Fluoride-Activated Disilane Species.

9. Recent progress in [11 C]carbon dioxide ([11 C]CO2 ) and [11 C]carbon monoxide ([11 C]CO) chemistry.

10. In-loop flow [11 C]CO2 fixation and radiosynthesis of N,N'-[11 C]dibenzylurea.

Review 3. Chemistry for Positron Emission Tomography: Recent Advances in ¹¹ C-, ¹⁸ F-, ¹³ N-, and ¹⁵ O-Labeling Reactions.

4. "In-loop" [¹¹ C]CO₂ fixation: Prototype and proof of concept.

6. From [¹¹C]CO₂ to [¹¹C]amides: a rapid one-pot synthesis via the Mitsunobu reaction.

8. Instantaneous Conversion of [¹¹ C]CO₂ to [¹¹ C]CO via Fluoride-Activated Disilane Species.

9. Recent progress in [¹¹ C]carbon dioxide ([¹¹ C]CO₂ ) and [¹¹ C]carbon monoxide ([¹¹ C]CO) chemistry.

10. In-loop flow [¹¹ C]CO₂ fixation and radiosynthesis of N,N'-[¹¹ C]dibenzylurea.