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Literature DB >> 23925392

Strontium ranelate: in search for the mechanism of action.

Abstract

Strontium ranelate is a medicine with evidenced effects on the risk of fractures. The heterogeneity of strontium distribution in bone, quality of bone mineral crystals in young bone packets on bone surfaces formed during strontium ranelate administration, and activation of the calcium sensing receptor may, at least partially, explain the beneficial effects of SrR on reducing the risk of fractures. In this review, the concept of the dual action of strontium ranelate is also discussed. However, sufficient evidence for the bone anabolic effect of SrR does not exist in humans. The knowledge of the mechanism of action of SrR is important not only for the explanation of the effects of SrR upon the skeleton, but also for the safety of treatment for other tissues.

Entities: Chemical Disease Gene Species

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Year: 2013 PMID： 23925392 DOI： 10.1007/s00774-013-0494-1

Source DB: PubMed Journal: J Bone Miner Metab ISSN： 0914-8779 Impact factor: 2.626

54 in total

Review 1. Hypercalcaemic and hypocalcaemic conditions due to calcium-sensing receptor mutations.

Authors: Ogo I Egbuna; Edward M Brown
Journal: Best Pract Res Clin Rheumatol Date: 2008-03 Impact factor: 4.098

2. Strontium is incorporated in different levels into bones and teeth of rats treated with strontium ranelate.

Authors: Josianne P Oliveira; William Querido; Rogério J Caldas; Andrea P C Campos; Leida G Abraçado; Marcos Farina
Journal: Calcif Tissue Int Date: 2012-07-18 Impact factor: 4.333

3. Microarchitectural deterioration of cortical and trabecular bone: differing effects of denosumab and alendronate.

Authors: Ego Seeman; Pierre D Delmas; David A Hanley; Deborah Sellmeyer; Angela M Cheung; Elizabeth Shane; Ann Kearns; Thierry Thomas; Steven K Boyd; Stephanie Boutroy; Cesar Bogado; Sharmila Majumdar; Michelle Fan; Cesar Libanati; Jose Zanchetta
Journal: J Bone Miner Res Date: 2010-08 Impact factor: 6.741

4. PTH (1-34), but not strontium ranelate counteract loss of trabecular thickness and bone strength in disuse osteopenic rats.

Authors: Annemarie Brüel; Jens Bay Vegger; Anders Christer Raffalt; Jens Enevold Thaulov Andersen; Jesper Skovhus Thomsen
Journal: Bone Date: 2012-12-11 Impact factor: 4.398

5. No difference between strontium ranelate (SR) and calcium/vitamin D on bone turnover markers in women with established osteoporosis previously treated with teriparatide: a randomized controlled trial.

Authors: Athanasios D Anastasilakis; Dimirtios G Goulis; Stergios A Polyzos; Spiridon Gerou; Iris Ballaouri; Zoe Efstathiadou; Marina Kita; Avraam Avramidis
Journal: Clin Endocrinol (Oxf) Date: 2009-04 Impact factor: 3.478

6. Efficacy and safety of strontium ranelate in the treatment of osteoporosis in men.

Authors: J-M Kaufman; M Audran; G Bianchi; V Braga; M Diaz-Curiel; R M Francis; S Goemaere; R Josse; S Palacios; J D Ringe; D Felsenberg; S Boonen
Journal: J Clin Endocrinol Metab Date: 2013-01-22 Impact factor: 5.958

7. Effect of long-term treatment with strontium ranelate on bone strontium content.

Authors: Olaf Bärenholdt; Niels Kolthoff; Stig Pors Nielsen
Journal: Bone Date: 2009-04-17 Impact factor: 4.398

8. Effects of strontium ranelate administration on calcium metabolism in female patients with postmenopausal osteoporosis and primary hyperparathyroidism.

Authors: Vincenzo Carnevale; Romano Del Fiacco; Elisabetta Romagnoli; Andrea Fontana; Cristiana Cipriani; Jessica Pepe; Salvatore Minisola
Journal: Calcif Tissue Int Date: 2012-10-19 Impact factor: 4.333

9. International Osteoporosis Foundation and International Federation of Clinical Chemistry and Laboratory Medicine position on bone marker standards in osteoporosis.

Authors: Samuel Vasikaran; Cyrus Cooper; Richard Eastell; Andrea Griesmacher; Howard A Morris; Tommaso Trenti; John A Kanis
Journal: Clin Chem Lab Med Date: 2011-05-24 Impact factor: 3.694

10. Influence of strontium on bone mineral density and bone mineral content measurements by dual X-ray absorptiometry.

Authors: S P Nielsen; D Slosman; O H Sørensen; B Basse-Cathalinat; P De Cassin; C R Roux; P J Meunier
Journal: J Clin Densitom Date: 1999 Impact factor: 2.963

14 in total

1. Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials.

Authors: Hélène Autefage; Eileen Gentleman; Elena Littmann; Martin A B Hedegaard; Thomas Von Erlach; Matthew O'Donnell; Frank R Burden; David A Winkler; Molly M Stevens
Journal: Proc Natl Acad Sci U S A Date: 2015-03-23 Impact factor: 11.205

2. Development of local strontium ranelate delivery systems and long term in vitro drug release studies in osteogenic medium.

Authors: Dagnija Loca; Anastasija Smirnova; Janis Locs; Arita Dubnika; Jana Vecstaudza; Liga Stipniece; Elina Makarova; Maija Dambrova
Journal: Sci Rep Date: 2018-11-13 Impact factor: 4.379

3. Effects of strontium ranelate treatment on osteoblasts cultivated onto scaffolds of trabeculae bovine bone.

Authors: Gerluza Aparecida Borges Silva; Bruno Machado Bertassoli; Cristiane Aparecida Sousa; Juliano Douglas Albergaria; Rayan Silva de Paula; Erika Cristina Jorge
Journal: J Bone Miner Metab Date: 2017-03-20 Impact factor: 2.626

Review 4. Bone-seeking agents for the treatment of bone disorders.

Authors: Jacqueline Cawthray; Ellen Wasan; Kishor Wasan
Journal: Drug Deliv Transl Res Date: 2017-08 Impact factor: 4.617

5. Effects of strontium ranelate on bone mass and bone turnover in women with thalassemia major-related osteoporosis.

Authors: Nunziata Morabito; Antonino Catalano; Agostino Gaudio; Elisabetta Morini; Lucia Maria Bruno; Giorgio Basile; Eleni Tsiantouli; Federica Bellone; Rita Maria Agostino; Basilia Piraino; Maria Angela La Rosa; Carmelo Salpietro; Antonino Lasco
Journal: J Bone Miner Metab Date: 2015-07-24 Impact factor: 2.626

6. Comparison of parathyroid hormone and strontium ranelate in combination with whole-body vibration in a rat model of osteoporosis.

Authors: D B Hoffmann; S Sehmisch; A M Hofmann; C Eimer; M Komrakova; D Saul; M Wassmann; K M Stürmer; M Tezval
Journal: J Bone Miner Metab Date: 2016-01-29 Impact factor: 2.626