Literature DB >> 23924243

Spiro fused diterpene-indole alkaloids from a creek-bottom-derived Aspergillus terreus.

Shengxin Cai1, Lin Du, Alexandra L Gerea, Jarrod B King, Jianlan You, Robert H Cichewicz.   

Abstract

Four metabolites, teraspiridoles A-D (2-5), formed from the merger of a diterpene and modified indole scaffold were obtained from an Aspergillus terreus isolate. The structures and absolute configurations of these natural products were established using NMR, mass spectrometry, Marfey's method, VCD, and ECD data. Teraspiridole B (3) exhibited weak inhibition of planaria regeneration/survival.

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Year:  2013        PMID： 23924243      PMCID： PMC3786142          DOI： 10.1021/ol401891z

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  14 in total

1.  The Kapakahines, Cyclic Peptides from the Marine Sponge Cribrochalina olemda.

Authors:  Bryan K. S. Yeung; Yoichi Nakao; Robin B. Kinnel; John R. Carney; Wesley Y. Yoshida; Paul J. Scheuer; Michelle Kelly-Borges
Journal:  J Org Chem       Date:  1996-10-04       Impact factor: 4.354

2.  Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an atlantic-forest-soil-derived Penicillium citreonigrum.

Authors:  Xiaoru Wang; José G Sena Filho; Ashley R Hoover; Jarrod B King; Trevor K Ellis; Douglas R Powell; Robert H Cichewicz
Journal:  J Nat Prod       Date:  2010-05-28       Impact factor: 4.050

3.  New quinazolinone alkaloids within rare amino acid residue from coral-associated fungus, Aspergillus versicolor LCJ-5-4.

Authors:  Yibin Zhuang; Xiancun Teng; Yi Wang; Peipei Liu; Guoqiang Li; Weiming Zhu
Journal:  Org Lett       Date:  2011-01-27       Impact factor: 6.005

4.  Waikialoid A suppresses hyphal morphogenesis and inhibits biofilm development in pathogenic Candida albicans.

Authors:  Xiaoru Wang; Jianlan You; Jarrod B King; Douglas R Powell; Robert H Cichewicz
Journal:  J Nat Prod       Date:  2012-03-08       Impact factor: 4.050

5.  Limonoids from the leaves of Toona ciliata var. yunnanensis.

Authors:  Jie-Qing Liu; Cui-Fang Wang; Yan Li; Jian-Chao Chen; Lin Zhou; Ming-Hua Qiu
Journal:  Phytochemistry       Date:  2012-01-23       Impact factor: 4.072

6.  Discovery of new natural products by application of X-hitting, a novel algorithm for automated comparison of full UV spectra, combined with structural determination by NMR spectroscopy.

Authors:  Thomas Ostenfeld Larsen; Bent O Petersen; Jens Ø Duus; Dan Sørensen; Jens C Frisvad; Michael E Hansen
Journal:  J Nat Prod       Date:  2005-06       Impact factor: 4.050

7.  Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015.

Authors:  Rui H Jiao; Shu Xu; Jun Y Liu; Hui M Ge; Hui Ding; Chen Xu; Hai L Zhu; Ren X Tan
Journal:  Org Lett       Date:  2006-12-07       Impact factor: 6.005

8.  Briarane diterpenes diminish COX-2 expression in human colon adenocarcinoma cells.

Authors:  P Matthew Joyner; Amanda L Waters; Russell B Williams; Douglas R Powell; Naveena B Janakiram; Chinthalapally V Rao; Robert H Cichewicz
Journal:  J Nat Prod       Date:  2011-03-25       Impact factor: 4.050

9.  Fungal indole alkaloid biosynthesis: genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum.

Authors:  Xue Gao; Yit-Heng Chooi; Brian D Ames; Peng Wang; Christopher T Walsh; Yi Tang
Journal:  J Am Chem Soc       Date:  2011-02-07       Impact factor: 15.419

10.  Evidence for horizontal transfer of a secondary metabolite gene cluster between fungi.

Authors:  Nora Khaldi; Jérôme Collemare; Marc-Henri Lebrun; Kenneth H Wolfe
Journal:  Genome Biol       Date:  2008-01-24       Impact factor: 13.583
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  5 in total

1.  An intramolecular cascade cyclization of 2-aryl indoles: efficient methods for the construction of 2,3-functionalized indolines and 3-indolinones.

Authors:  Arun K Ghosh; Zhi-Hua Chen
Journal:  Org Biomol Chem       Date:  2014-05-01       Impact factor: 3.876

2.  Bioactive sulfur-containing sulochrin dimers and other metabolites from an Alternaria sp. isolate from a Hawaiian soil sample.

Authors:  Shengxin Cai; Jarrod B King; Lin Du; Douglas R Powell; Robert H Cichewicz
Journal:  J Nat Prod       Date:  2014-09-29       Impact factor: 4.050

3.  A potent HDAC inhibitor, 1-alaninechlamydocin, from a Tolypocladium sp. induces G2/M cell cycle arrest and apoptosis in MIA PaCa-2 cells.

Authors:  Lin Du; April L Risinger; Jarrod B King; Douglas R Powell; Robert H Cichewicz
Journal:  J Nat Prod       Date:  2014-07-07       Impact factor: 4.050

4.  Chlorinated polyketide obtained from a Daldinia sp. treated with the epigenetic modifier suberoylanilide hydroxamic acid.

Authors:  Lin Du; Jarrod B King; Robert H Cichewicz
Journal:  J Nat Prod       Date:  2014-10-22       Impact factor: 4.050

5.  Polyketide glycosides from Bionectria ochroleuca inhibit Candida albicans biofilm formation.

Authors:  Bin Wang; Jianlan You; Jarrod B King; Shengxin Cai; Elizabeth Park; Douglas R Powell; Robert H Cichewicz
Journal:  J Nat Prod       Date:  2014-10-10       Impact factor: 4.050
  5 in total

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