| Literature DB >> 21438584 |
P Matthew Joyner1, Amanda L Waters, Russell B Williams, Douglas R Powell, Naveena B Janakiram, Chinthalapally V Rao, Robert H Cichewicz.
Abstract
Exploration of a soft coral (Briareum sp.) from Vanuatu led to the isolation of three new briaranes, designated brialalepolides A (1), B (2), and C (3). Compounds 2 and 3 reduced the expression of COX-2 in human colon adenocarcinoma cells, as well as in murine macrophage cells. This is significant because the metabolic products of COX-2 have been implicated in the pathogenesis of colon cancer and other diseases.Entities:
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Year: 2011 PMID： 21438584 DOI： 10.1021/np100775a
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050