Rob A R Gons1, Anil M Tuladhar, Karlijn F de Laat, Anouk G W van Norden, Ewoud J van Dijk, David G Norris, Marcel P Zwiers, Frank-Erik de Leeuw. 1. From the Department of Neurology (R.A.R.G.), Catharina Hospital, Eindhoven; Donders Institute for Brain, Cognition and Behavior, Center for Neuroscience, Departments of Neurology (R.A.R.G., A.M.T., K.F.d. L., A.G.W.v.N., E.J.v.D., F.-E.d.L.) and Psychiatry (M.P.Z.), Radboud University Nijmegen Medical Center; and Donders Institute for Brain, Cognition and Behavior, Center for Cognitive Neuroimaging, Radboud University Nijmegen (D.G.N., M.P.Z.), the Netherlands.
Abstract
OBJECTIVE: To investigate the relation between physical exercise and the microstructural integrity of cerebral white matter. METHODS: Four hundred forty individuals with cerebral small-vessel disease, aged between 50 and 85 years, without dementia, were included and underwent MRI scanning. Physical exercise was assessed with a structured questionnaire. The cross-sectional relation between physical exercise and the microstructural integrity of the white matter was assessed by applying Tract-Based Spatial Statistics to diffusion tensor imaging parameters. RESULTS: Being more physically active was negatively related to the mean, axial, and radial diffusivity in numerous regions of the white matter, indicative of higher white matter integrity. CONCLUSIONS: These data indicate an association between physical activity and the integrity of the cerebral white matter's microstructure. Prospective studies are required to investigate a possible causal association between physical activity and cognitive decline.
OBJECTIVE: To investigate the relation between physical exercise and the microstructural integrity of cerebral white matter. METHODS: Four hundred forty individuals with cerebral small-vessel disease, aged between 50 and 85 years, without dementia, were included and underwent MRI scanning. Physical exercise was assessed with a structured questionnaire. The cross-sectional relation between physical exercise and the microstructural integrity of the white matter was assessed by applying Tract-Based Spatial Statistics to diffusion tensor imaging parameters. RESULTS: Being more physically active was negatively related to the mean, axial, and radial diffusivity in numerous regions of the white matter, indicative of higher white matter integrity. CONCLUSIONS: These data indicate an association between physical activity and the integrity of the cerebral white matter's microstructure. Prospective studies are required to investigate a possible causal association between physical activity and cognitive decline.
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