Literature DB >> 23917226

Synthesis and evaluation of phosphorodithioate-based hydrogen sulfide donors.

Chung-Min Park1, Yu Zhao, Zhaohui Zhu, Armando Pacheco, Bo Peng, Nelmi O Devarie-Baez, Powell Bagdon, Hui Zhang, Ming Xian.   

Abstract

A series of pan class="Chemical">O-aryl- and alkyl-substituted phosphorodithioatesn> were designed and synthesized as pan class="Chemical">hydrogen sulfide (pan class="Gene">H2S) donors. H2S releasing capability of these compounds was evaluated using fluorescence methods. O-aryl substituted donors showed slow and sustained H2S release while O-alkylated compounds showed very weak H2S releasing capability. We also evaluated donors' protective effects against hydrogen peroxide (H2O2)-induced oxidative damage in myocytes and donors' toxicity toward B16BL6 mouse melanoma cells.

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Year:  2013        PMID： 23917226      PMCID： PMC3789624          DOI： 10.1039/c3mb70145j

Source DB:  PubMed          Journal:  Mol Biosyst        ISSN： 1742-2051


  36 in total

1.  Controllable hydrogen sulfide donors and their activity against myocardial ischemia-reperfusion injury.

Authors:  Yu Zhao; Shashi Bhushan; Chuntao Yang; Hiroyuki Otsuka; Jason D Stein; Armando Pacheco; Bo Peng; Nelmi O Devarie-Baez; Hector C Aguilar; David J Lefer; Ming Xian
Journal:  ACS Chem Biol       Date:  2013-04-16       Impact factor: 5.100

2.  Redox biochemistry of hydrogen sulfide.

Authors:  Omer Kabil; Ruma Banerjee
Journal:  J Biol Chem       Date:  2010-05-06       Impact factor: 5.157

3.  Hydrogen sulfide-mediated cardioprotection: mechanisms and therapeutic potential.

Authors:  Madhav Lavu; Shashi Bhushan; David J Lefer
Journal:  Clin Sci (Lond)       Date:  2011-03       Impact factor: 6.124

4.  Regulation of heart function by endogenous gaseous mediators-crosstalk between nitric oxide and hydrogen sulfide.

Authors:  Qian-Chen Yong; Jia Ling Cheong; Fei Hua; Lih-Wen Deng; Yok Moi Khoo; How-Sung Lee; Alexis Perry; Mark Wood; Matthew Whiteman; Jin-Song Bian
Journal:  Antioxid Redox Signal       Date:  2011-03-17       Impact factor: 8.401

Review 5.  Synthesis and biological effects of hydrogen sulfide (H2S): development of H2S-releasing drugs as pharmaceuticals.

Authors:  Giuseppe Caliendo; Giuseppe Cirino; Vincenzo Santagada; John L Wallace
Journal:  J Med Chem       Date:  2010-09-09       Impact factor: 7.446

Review 6.  Hydrogen sulfide and cell signaling.

Authors:  Ling Li; Peter Rose; Philip K Moore
Journal:  Annu Rev Pharmacol Toxicol       Date:  2011       Impact factor: 13.820

7.  Cysteine-activated hydrogen sulfide (H2S) donors.

Authors:  Yu Zhao; Hua Wang; Ming Xian
Journal:  J Am Chem Soc       Date:  2010-12-10       Impact factor: 15.419

Review 8.  Hydrogen sulfide: its production, release and functions.

Authors:  Hideo Kimura
Journal:  Amino Acids       Date:  2010-02-27       Impact factor: 3.520

9.  H2S signals through protein S-sulfhydration.

Authors:  Asif K Mustafa; Moataz M Gadalla; Nilkantha Sen; Seyun Kim; Weitong Mu; Sadia K Gazi; Roxanne K Barrow; Guangdong Yang; Rui Wang; Solomon H Snyder
Journal:  Sci Signal       Date:  2009-11-10       Impact factor: 8.192

Review 10.  Measurement and biological significance of the volatile sulfur compounds hydrogen sulfide, methanethiol and dimethyl sulfide in various biological matrices.

Authors:  Albert Tangerman
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2009-05-21       Impact factor: 3.205
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  17 in total

1.  Fluorescent probes based on nucleophilic substitution-cyclization for hydrogen sulfide detection and bioimaging.

Authors:  Bo Peng; Wei Chen; Chunrong Liu; Ethan W Rosser; Armando Pacheco; Yu Zhao; Hector C Aguilar; Ming Xian
Journal:  Chemistry       Date:  2013-12-11       Impact factor: 5.236

Review 2.  A review of hydrogen sulfide (H2S) donors: Chemistry and potential therapeutic applications.

Authors:  Chadwick R Powell; Kearsley M Dillon; John B Matson
Journal:  Biochem Pharmacol       Date:  2017-11-23       Impact factor: 5.858

Review 3.  Activatable Small-Molecule Hydrogen Sulfide Donors.

Authors:  Carolyn M Levinn; Matthew M Cerda; Michael D Pluth
Journal:  Antioxid Redox Signal       Date:  2019-10-29       Impact factor: 8.401

4.  Cyclic Sulfenyl Thiocarbamates Release Carbonyl Sulfide and Hydrogen Sulfide Independently in Thiol-Promoted Pathways.

Authors:  Yu Zhao; Andrea K Steiger; Michael D Pluth
Journal:  J Am Chem Soc       Date:  2019-08-14       Impact factor: 15.419

Review 5.  Chemical Biology of H2S Signaling through Persulfidation.

Authors:  Milos R Filipovic; Jasmina Zivanovic; Beatriz Alvarez; Ruma Banerjee
Journal:  Chem Rev       Date:  2017-11-07       Impact factor: 60.622

Review 6.  Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications.

Authors:  Yu Zhao; Tyler D Biggs; Ming Xian
Journal:  Chem Commun (Camb)       Date:  2014-10-14       Impact factor: 6.222

Review 7.  International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors.

Authors:  Csaba Szabo; Andreas Papapetropoulos
Journal:  Pharmacol Rev       Date:  2017-10       Impact factor: 25.468

8.  Sulfur-containing therapeutics in the treatment of Alzheimer's disease.

Authors:  Haizhou Zhu; Venkateshwara Dronamraju; Wei Xie; Swati S More
Journal:  Med Chem Res       Date:  2021-01-15       Impact factor: 1.965

Review 9.  Hydrogen sulfide prodrugs-a review.

Authors:  Yueqin Zheng; Xingyue Ji; Kaili Ji; Binghe Wang
Journal:  Acta Pharm Sin B       Date:  2015-08-21       Impact factor: 11.413

10.  A Dinuclear Persulfide-Bridged Ruthenium Compound is a Hypoxia-Selective Hydrogen Sulfide (H2 S) Donor.

Authors:  Joshua J Woods; Justin J Wilson
Journal:  Angew Chem Int Ed Engl       Date:  2020-11-16       Impact factor: 15.336
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