Literature DB >> 19903941

H2S signals through protein S-sulfhydration.

Asif K Mustafa1, Moataz M Gadalla, Nilkantha Sen, Seyun Kim, Weitong Mu, Sadia K Gazi, Roxanne K Barrow, Guangdong Yang, Rui Wang, Solomon H Snyder.   

Abstract

Hydrogen sulfide (H2S), a messenger molecule generated by cystathionine gamma-lyase, acts as a physiologic vasorelaxant. Mechanisms whereby H2S signals have been elusive. We now show that H2S physiologically modifies cysteines in a large number of proteins by S-sulfhydration. About 10 to 25% of many liver proteins, including actin, tubulin, and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), are sulfhydrated under physiological conditions. Sulfhydration augments GAPDH activity and enhances actin polymerization. Sulfhydration thus appears to be a physiologic posttranslational modification for proteins.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19903941      PMCID： PMC2998899          DOI： 10.1126/scisignal.2000464

Source DB:  PubMed          Journal:  Sci Signal        ISSN： 1945-0877            Impact factor:   8.192


  21 in total

Review 1.  Putative biological roles of hydrogen sulfide in health and disease: a breath of not so fresh air?

Authors:  L Li; P K Moore
Journal:  Trends Pharmacol Sci       Date:  2008-01-03       Impact factor: 14.819

2.  Activation of KATP channels by H2S in rat insulin-secreting cells and the underlying mechanisms.

Authors:  Wei Yang; Guangdong Yang; Xuming Jia; Lingyun Wu; Rui Wang
Journal:  J Physiol       Date:  2005-09-22       Impact factor: 5.182

Review 3.  Protein S-nitrosylation: purview and parameters.

Authors:  Douglas T Hess; Akio Matsumoto; Sung-Oog Kim; Harvey E Marshall; Jonathan S Stamler
Journal:  Nat Rev Mol Cell Biol       Date:  2005-02       Impact factor: 94.444

4.  Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function.

Authors:  John W Elrod; John W Calvert; Joanna Morrison; Jeannette E Doeller; David W Kraus; Ling Tao; Xiangying Jiao; Rosario Scalia; Levente Kiss; Csaba Szabo; Hideo Kimura; Chi-Wing Chow; David J Lefer
Journal:  Proc Natl Acad Sci U S A       Date:  2007-09-18       Impact factor: 11.205

5.  Hydrogen sulfide mediates the vasoactivity of garlic.

Authors:  Gloria A Benavides; Giuseppe L Squadrito; Robert W Mills; Hetal D Patel; T Scott Isbell; Rakesh P Patel; Victor M Darley-Usmar; Jeannette E Doeller; David W Kraus
Journal:  Proc Natl Acad Sci U S A       Date:  2007-10-19       Impact factor: 11.205

6.  Hydrogen sulfide increases thermotolerance and lifespan in Caenorhabditis elegans.

Authors:  Dana L Miller; Mark B Roth
Journal:  Proc Natl Acad Sci U S A       Date:  2007-12-12       Impact factor: 11.205

7.  Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins.

Authors:  Moran Benhar; Michael T Forrester; Douglas T Hess; Jonathan S Stamler
Journal:  Science       Date:  2008-05-23       Impact factor: 47.728

Review 8.  Hydrogen sulphide and its therapeutic potential.

Authors:  Csaba Szabó
Journal:  Nat Rev Drug Discov       Date:  2007-11       Impact factor: 84.694

9.  H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase.

Authors:  Guangdong Yang; Lingyun Wu; Bo Jiang; Wei Yang; Jiansong Qi; Kun Cao; Qinghe Meng; Asif K Mustafa; Weitong Mu; Shengming Zhang; Solomon H Snyder; Rui Wang
Journal:  Science       Date:  2008-10-24       Impact factor: 47.728

10.  Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis.

Authors:  Nilkantha Sen; Makoto R Hara; Michael D Kornberg; Matthew B Cascio; Byoung-Il Bae; Neelam Shahani; Bobby Thomas; Ted M Dawson; Valina L Dawson; Solomon H Snyder; Akira Sawa
Journal:  Nat Cell Biol       Date:  2008-06-15       Impact factor: 28.824
View more
  436 in total

1.  Hydrogen sulfide is an endogenous potentiator of T cell activation.

Authors:  Thomas W Miller; Evelyn A Wang; Serge Gould; Erica V Stein; Sukhbir Kaur; Langston Lim; Shoba Amarnath; Daniel H Fowler; David D Roberts
Journal:  J Biol Chem       Date:  2011-12-13       Impact factor: 5.157

2.  H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response.

Authors:  Navasona Krishnan; Cexiong Fu; Darryl J Pappin; Nicholas K Tonks
Journal:  Sci Signal       Date:  2011-12-13       Impact factor: 8.192

Review 3.  Regulation of Aqueous Humor Dynamics by Hydrogen Sulfide: Potential Role in Glaucoma Pharmacotherapy.

Authors:  Sunny E Ohia; Jenaye Robinson; Leah Mitchell; Kalu K Ngele; Segewkal Heruye; Catherine A Opere; Ya Fatou Njie-Mbye
Journal:  J Ocul Pharmacol Ther       Date:  2017-12-07       Impact factor: 2.671

Review 4.  Reactive nitrogen species and hydrogen sulfide as regulators of protein tyrosine phosphatase activity.

Authors:  Petr Heneberg
Journal:  Antioxid Redox Signal       Date:  2014-03-11       Impact factor: 8.401

5.  Detection of protein S-sulfhydration by a tag-switch technique.

Authors:  Dehui Zhang; Igor Macinkovic; Nelmi O Devarie-Baez; Jia Pan; Chung-Min Park; Kate S Carroll; Milos R Filipovic; Ming Xian
Journal:  Angew Chem Int Ed Engl       Date:  2013-11-29       Impact factor: 15.336

6.  Cupriavidus necator H16 Uses Flavocytochrome c Sulfide Dehydrogenase To Oxidize Self-Produced and Added Sulfide.

Authors:  Chuanjuan Lü; Yongzhen Xia; Daixi Liu; Rui Zhao; Rui Gao; Honglei Liu; Luying Xun
Journal:  Appl Environ Microbiol       Date:  2017-10-31       Impact factor: 4.792

7.  The Development of Fluorescent Probes for Visualizing Intracellular Hydrogen Polysulfides.

Authors:  Wei Chen; Ethan W Rosser; Tetsuro Matsunaga; Armando Pacheco; Takaaki Akaike; Ming Xian
Journal:  Angew Chem Int Ed Engl       Date:  2015-09-18       Impact factor: 15.336

Review 8.  Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Remodeling.

Authors:  Shuai Yuan; Christopher G Kevil
Journal:  Microcirculation       Date:  2016-02       Impact factor: 2.628

9.  Hydrogen sulfide treatment reduces blood pressure and oxidative stress in angiotensin II-induced hypertensive mice.

Authors:  Mohammad R Al-Magableh; Barbara K Kemp-Harper; Joanne L Hart
Journal:  Hypertens Res       Date:  2014-08-07       Impact factor: 3.872

10.  S-sulfhydration of MEK1 leads to PARP-1 activation and DNA damage repair.

Authors:  Kexin Zhao; YoungJun Ju; Shuangshuang Li; Zaid Altaany; Rui Wang; Guangdong Yang
Journal:  EMBO Rep       Date:  2014-04-28       Impact factor: 8.807
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.