OBJECTIVE: Our purpose was to determine associations between HLA alleles and psoriatic arthritis (PsA). METHODS: 678 PsA cases and 688 healthy controls were analyzed in a case-control design. The difference in the proportion of cases and controls with at least 1 copy of HLA alleles were tested for significance using χ(2) test and Fisher's exact test. Association analyses of haplotypes inferred by the Expectation-Maximization algorithm were performed. In the family-based association study, data from 283 families were analyzed. RESULTS: Univariate analysis revealed that cases were more likely to be carriers of HLA-C*01, -C*02, -C*06, -C*12, -B*27, -B*38 and -B*57, whereas controls were more likely to be carriers of HLA-C*03, -C*07, -B*07, -B*51, -DRB1*15 and -DQB1*0602. In haplotype analyses, PsA cases were more likely to be carriers of the HLA haplotypes -C*01/-B*27, -C*02/-B*27, -C*12/-B*38, and -C*06/-B*57, while controls were more likely to be carriers of the haplotypes -C*07/-B*07 and -C*15/-B*51. In the family-based association analysis, the HLA alleles -A*02, -B*27 and -DRB1*07 were preferentially transmitted to cases, whereas the alleles -A*03, -A*28, -B*51, -DRB1*11 and -DQB1*0301 were under transmitted. CONCLUSION: This large case-control and family based association study shows that HLA-C*12/B*38, HLA-B*27 and HLA-C*06/B*57 are haplotypes (alleles) robustly associated with PsA. However, since patients with PsA also have psoriasis it is difficult to determine whether the primary association is with arthritis or psoriasis.
OBJECTIVE: Our purpose was to determine associations between HLA alleles and psoriatic arthritis (PsA). METHODS: 678 PsA cases and 688 healthy controls were analyzed in a case-control design. The difference in the proportion of cases and controls with at least 1 copy of HLA alleles were tested for significance using χ(2) test and Fisher's exact test. Association analyses of haplotypes inferred by the Expectation-Maximization algorithm were performed. In the family-based association study, data from 283 families were analyzed. RESULTS: Univariate analysis revealed that cases were more likely to be carriers of HLA-C*01, -C*02, -C*06, -C*12, -B*27, -B*38 and -B*57, whereas controls were more likely to be carriers of HLA-C*03, -C*07, -B*07, -B*51, -DRB1*15 and -DQB1*0602. In haplotype analyses, PsA cases were more likely to be carriers of the HLA haplotypes -C*01/-B*27, -C*02/-B*27, -C*12/-B*38, and -C*06/-B*57, while controls were more likely to be carriers of the haplotypes -C*07/-B*07 and -C*15/-B*51. In the family-based association analysis, the HLA alleles -A*02, -B*27 and -DRB1*07 were preferentially transmitted to cases, whereas the alleles -A*03, -A*28, -B*51, -DRB1*11 and -DQB1*0301 were under transmitted. CONCLUSION: This large case-control and family based association study shows that HLA-C*12/B*38, HLA-B*27 and HLA-C*06/B*57 are haplotypes (alleles) robustly associated with PsA. However, since patients with PsA also have psoriasis it is difficult to determine whether the primary association is with arthritis or psoriasis.
Authors: Philip E Stuart; Rajan P Nair; Lam C Tsoi; Trilokraj Tejasvi; Sayantan Das; Hyun Min Kang; Eva Ellinghaus; Vinod Chandran; Kristina Callis-Duffin; Robert Ike; Yanming Li; Xiaoquan Wen; Charlotta Enerbäck; Johann E Gudjonsson; Sulev Kõks; Külli Kingo; Tõnu Esko; Ulrich Mrowietz; Andre Reis; H Erich Wichmann; Christian Gieger; Per Hoffmann; Markus M Nöthen; Juliane Winkelmann; Manfred Kunz; Elvia G Moreta; Philip J Mease; Christopher T Ritchlin; Anne M Bowcock; Gerald G Krueger; Henry W Lim; Stephan Weidinger; Michael Weichenthal; John J Voorhees; Proton Rahman; Peter K Gregersen; Andre Franke; Dafna D Gladman; Gonçalo R Abecasis; James T Elder Journal: Am J Hum Genet Date: 2015-11-28 Impact factor: 11.025
Authors: Georg Schett; Proton Rahman; Christopher Ritchlin; Iain B McInnes; Dirk Elewaut; Jose U Scher Journal: Nat Rev Rheumatol Date: 2022-05-05 Impact factor: 20.543
Authors: Christos Tziotzios; Christos Petridis; Nick Dand; Chrysanthi Ainali; Jake R Saklatvala; Venu Pullabhatla; Alexandros Onoufriadis; Rashida Pramanik; David Baudry; Sang Hyuck Lee; Kristie Wood; Lu Liu; Seth Seegobin; Gregory A Michelotti; Su M Lwin; Evangelos A A Christou; Charles J Curtis; Emanuele de Rinaldis; Alka Saxena; Susan Holmes; Matthew Harries; Ioulios Palamaras; Fiona Cunningham; Gregory Parkins; Manjit Kaur; Paul Farrant; Andrew McDonagh; Andrew Messenger; Jennifer Jones; Victoria Jolliffe; Iaisha Ali; Michael Ardern-Jones; Charles Mitchell; Nigel Burrows; Ravinder Atkar; Cedric Banfield; Anton Alexandroff; Caroline Champagne; Hywel L Cooper; Sergio Vañó-Galván; Ana Maria Molina-Ruiz; Nerea Ormaechea Perez; Girish K Patel; Abby Macbeth; Melanie Page; Alyson Bryden; Megan Mowbray; Shyamal Wahie; Keith Armstrong; Nicola Cooke; Mark Goodfield; Irene Man; David de Berker; Giles Dunnill; Anita Takwale; Archana Rao; Tee-Wei Siah; Rodney Sinclair; Martin S Wade; Ncoza C Dlova; Jane Setterfield; Fiona Lewis; Kapil Bhargava; Niall Kirkpatrick; Xavier Estivill; Catherine M Stefanato; Carsten Flohr; Timothy Spector; Fiona M Watt; Catherine H Smith; Jonathan N Barker; David A Fenton; Michael A Simpson; John A McGrath Journal: Nat Commun Date: 2019-03-08 Impact factor: 14.919
Authors: Yukinori Okada; Buhm Han; Lam C Tsoi; Philip E Stuart; Eva Ellinghaus; Trilokraj Tejasvi; Vinod Chandran; Fawnda Pellett; Remy Pollock; Anne M Bowcock; Gerald G Krueger; Michael Weichenthal; John J Voorhees; Proton Rahman; Peter K Gregersen; Andre Franke; Rajan P Nair; Gonçalo R Abecasis; Dafna D Gladman; James T Elder; Paul I W de Bakker; Soumya Raychaudhuri Journal: Am J Hum Genet Date: 2014-07-31 Impact factor: 11.025
Authors: Haider H Zalzala; Galawish A Abdullah; Mohammed Y Abbas; Hyam R Mohammedsalih; Batool M Mahdi Journal: Saudi Med J Date: 2018-09 Impact factor: 1.484