Rushikesh Sheth1, Maria Félix Bastida, Marie Kmita, Marian Ros. 1. Instituto de Biomedicina y Biotecnologéa de Cantabria, . CSIC-SODERCAN-Universidad de Cantabria, Santander, Spain; Institut de Recherches Cliniques de Montréal, Montréal, QC, Canada.
Abstract
BACKGROUND: Precise temporal and spatial expression of the clustered Hox genes is essential for patterning the developing embryo. Temporal activation of Hox genes was shown to be cluster-autonomous. However, gene clustering appears dispensable for spatial colinear expression. Generally, a set of Hox genes expressed in a group of cells instructs these cells about their fate such that the differential expression of Hox genes results in morphological diversity. The spatial colinearity is considered to rely both on local and long-range cis regulation. RESULTS: Here, we report on the global deregulation of HoxA and HoxD expression patterns upon inactivation of a subset of HOXA and HOXD proteins. CONCLUSIONS: Our data suggest the existence of a "self-regulation" mechanism, a process by which HOX proteins establish and/or maintain the spatial domains of the Hox gene family and we propose that the functionally dominant HOX proteins could contribute to generating the spatial parameters of Hox expression in a given tissue, i.e., HOX controlling the establishment of the ultimate HOX code.
BACKGROUND: Precise temporal and spatial expression of the clustered Hox genes is essential for patterning the developing embryo. Temporal activation of Hox genes was shown to be cluster-autonomous. However, gene clustering appears dispensable for spatial colinear expression. Generally, a set of Hox genes expressed in a group of cells instructs these cells about their fate such that the differential expression of Hox genes results in morphological diversity. The spatial colinearity is considered to rely both on local and long-range cis regulation. RESULTS: Here, we report on the global deregulation of HoxA and HoxD expression patterns upon inactivation of a subset of HOXA and HOXD proteins. CONCLUSIONS: Our data suggest the existence of a "self-regulation" mechanism, a process by which HOX proteins establish and/or maintain the spatial domains of the Hox gene family and we propose that the functionally dominant HOX proteins could contribute to generating the spatial parameters of Hox expression in a given tissue, i.e., HOX controlling the establishment of the ultimate HOX code.
Authors: Rushikesh Sheth; Damien Grégoire; Annie Dumouchel; Martina Scotti; Jessica My Trang Pham; Stephen Nemec; Maria Félix Bastida; Marian A Ros; Marie Kmita Journal: Development Date: 2013-05 Impact factor: 6.868
Authors: Yacine Kherdjemil; Robert L Lalonde; Rushikesh Sheth; Annie Dumouchel; Gemma de Martino; Kyriel M Pineault; Deneen M Wellik; H Scott Stadler; Marie-Andrée Akimenko; Marie Kmita Journal: Nature Date: 2016-10-05 Impact factor: 49.962
Authors: Maria Félix Bastida; Rocío Pérez-Gómez; Anna Trofka; Jianjian Zhu; Alvaro Rada-Iglesias; Rushikesh Sheth; H Scott Stadler; Susan Mackem; Marian A Ros Journal: Proc Natl Acad Sci U S A Date: 2020-01-02 Impact factor: 11.205
Authors: Elisabeth Zieger; Simona Candiani; Greta Garbarino; Jenifer C Croce; Michael Schubert Journal: Mol Neurobiol Date: 2017-09-05 Impact factor: 5.590