| Literature DB >> 1673231 |
J C Izpisúa-Belmonte1, C Tickle, P Dollé, L Wolpert, D Duboule.
Abstract
The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application of retinoic acid, a putative endogenous morphogen, induces de novo transcription of Hox-4 genes. The mirror-image patterns of Hox-4 gene expression, which are obtained in this way, correlate with the subsequent development of mirror-image patterns of digits. Hox-4 genes probably encode positional information.Entities:
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Year: 1991 PMID: 1673231 DOI: 10.1038/350585a0
Source DB: PubMed Journal: Nature ISSN: 0028-0836 Impact factor: 49.962