BACKGROUND: A simple endoscopic classification to accurately predict deep submucosal invasive (SM-d) carcinoma would be clinically useful. OBJECTIVE: To develop and assess the validity of the NBI international colorectal endoscopic (NICE) classification for the characterization of SM-d carcinoma. DESIGN: The study was conducted in 4 phases: (1) evaluation of endoscopic differentiation by NBI-experienced colonoscopists; (2) extension of the NICE classification to incorporate SM-d (type 3) by using a modified Delphi method; (3) prospective validation of the individual criteria by inexperienced participants, by using high-definition still images without magnification of known histology; and (4) prospective validation of the individual criteria and overall classification by inexperienced participants after training. SETTING: Japanese academic unit. MAIN OUTCOME MEASUREMENTS: Performance characteristics of the NICE criteria (phase 3) and overall classification (phase 4) for SM-d carcinoma; sensitivity, specificity, predictive values, and accuracy. RESULTS: We expanded the NICE classification for the endoscopic diagnosis of SM-d carcinoma (type 3) and established the predictive validity of its individual components. The negative predictive values of the individual criteria for diagnosis of SM-d carcinoma were 76.2% (color), 88.5% (vessels), and 79.1% (surface pattern). When any 1 of the 3 SM-d criteria was present, the sensitivity was 94.9%, and the negative predictive value was 95.9%. The overall sensitivity and negative predictive value of a global, high-confidence prediction of SM-d carcinoma was 92%. Interobserver agreement for an overall SM-d carcinoma prediction was substantial (kappa 0.70). LIMITATIONS: Single Japanese center, use of still images without prospective clinical evaluation. CONCLUSION: The NICE classification is a valid tool for predicting SM-d carcinomas in colorectal tumors.
BACKGROUND: A simple endoscopic classification to accurately predict deep submucosal invasive (SM-d) carcinoma would be clinically useful. OBJECTIVE: To develop and assess the validity of the NBI international colorectal endoscopic (NICE) classification for the characterization of SM-dcarcinoma. DESIGN: The study was conducted in 4 phases: (1) evaluation of endoscopic differentiation by NBI-experienced colonoscopists; (2) extension of the NICE classification to incorporate SM-d (type 3) by using a modified Delphi method; (3) prospective validation of the individual criteria by inexperienced participants, by using high-definition still images without magnification of known histology; and (4) prospective validation of the individual criteria and overall classification by inexperienced participants after training. SETTING: Japanese academic unit. MAIN OUTCOME MEASUREMENTS: Performance characteristics of the NICE criteria (phase 3) and overall classification (phase 4) for SM-dcarcinoma; sensitivity, specificity, predictive values, and accuracy. RESULTS: We expanded the NICE classification for the endoscopic diagnosis of SM-dcarcinoma (type 3) and established the predictive validity of its individual components. The negative predictive values of the individual criteria for diagnosis of SM-dcarcinoma were 76.2% (color), 88.5% (vessels), and 79.1% (surface pattern). When any 1 of the 3 SM-d criteria was present, the sensitivity was 94.9%, and the negative predictive value was 95.9%. The overall sensitivity and negative predictive value of a global, high-confidence prediction of SM-dcarcinoma was 92%. Interobserver agreement for an overall SM-dcarcinoma prediction was substantial (kappa 0.70). LIMITATIONS: Single Japanese center, use of still images without prospective clinical evaluation. CONCLUSION: The NICE classification is a valid tool for predicting SM-dcarcinomas in colorectal tumors.
Authors: F Bianco; A Arezzo; F Agresta; C Coco; R Faletti; Z Krivocapic; G Rotondano; G A Santoro; N Vettoretto; S De Franciscis; A Belli; G M Romano Journal: Tech Coloproctol Date: 2015-09-24 Impact factor: 3.781
Authors: Sascha C van Doorn; Y Hazewinkel; James E East; Monique E van Leerdam; Amit Rastogi; Maria Pellisé; Silvia Sanduleanu-Dascalescu; Barbara A J Bastiaansen; Paul Fockens; Evelien Dekker Journal: Am J Gastroenterol Date: 2014-10-21 Impact factor: 10.864