| Literature DB >> 23909824 |
Giada Arena1, C Chun Chen, Daniele Leonori, Varinder K Aggarwal.
Abstract
3-Methyl vinyl aziridine undergoes a mild MgI2-promoted S(N)2' ring opening and concomitant cyclization with fumarate Michael acceptors to give trisubstituted pyrrolidines. The process is efficient and highly diastereoselective. This methodology has been applied to a concise asymmetric synthesis of (+)-allo-kainic acid.Entities:
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Year: 2013 PMID： 23909824 DOI： 10.1021/ol4020333
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005