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Literature DB >> 23907791

Role of COMT in ADHD: a systematic meta-analysis.

Hongjuan Sun¹, Fangfen Yuan, Xuemei Shen, Guanglian Xiong, Jing Wu.

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable childhood-onset psychiatric disorder with significant genetic contribution. Considerable evidence has implicated involvement of dopaminergic system and the prefrontal cortex (PFC) in the pathomechanism of ADHD. The catechol-O-methyltransferase (COMT) gene is of particular interest for ADHD as its crucial role in the degradation of dopamine in the PFC. We summarized the reported findings investigating associations between COMT gene and ADHD and performed a meta-analysis of previous studies to assess the overall magnitude and significance of the association.

Entities: Chemical Disease Gene

Mesh：

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Year: 2013 PMID： 23907791 DOI： 10.1007/s12035-013-8516-5

Source DB: PubMed Journal: Mol Neurobiol ISSN： 0893-7648 Impact factor: 5.590

131 in total

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