OBJECTIVE: This study assesses the effect of attention-deficit hyperactivity disorder (ADHD) and gender on cerebral glucose metabolism (CMRglu), using positron emission tomography and 18F-fluorodeoxyglucose. METHOD: Nineteen normal (6 females; 14.3 +/- 1.3 years old) and 20 ADHD adolescents (5 females; 14.7 +/- 1.6 years old) participated in the study. An auditory continuous performance task was used during the 30-minute uptake of 18F-fluorodeoxyglucose. RESULTS: There were no statistically significant differences in global or regional CMRglu between ADHD (N = 20) and normal (N = 19) adolescents. However, the global CMRglu in ADHD girls (N = 5) was 15.0% lower than in normal girls (N = 6) (p = .04), while global CMRglu in ADHD boys was not different than in normal boys. Furthermore, global CMRglu in ADHD girls was 19.6% lower than in ADHD boys (p = .02) and was not different between normal girls and normal boys. Clinical rating scales did not differentiate ADHD girls from ADHD boys, nor normal girls from normal boys. CONCLUSIONS: The greater brain metabolism abnormalities in females than males strongly stress that more attention be given to the study of girls with ADHD.
OBJECTIVE: This study assesses the effect of attention-deficit hyperactivity disorder (ADHD) and gender on cerebral glucose metabolism (CMRglu), using positron emission tomography and 18F-fluorodeoxyglucose. METHOD: Nineteen normal (6 females; 14.3 +/- 1.3 years old) and 20 ADHD adolescents (5 females; 14.7 +/- 1.6 years old) participated in the study. An auditory continuous performance task was used during the 30-minute uptake of 18F-fluorodeoxyglucose. RESULTS: There were no statistically significant differences in global or regional CMRglu between ADHD (N = 20) and normal (N = 19) adolescents. However, the global CMRglu in ADHDgirls (N = 5) was 15.0% lower than in normal girls (N = 6) (p = .04), while global CMRglu in ADHDboys was not different than in normal boys. Furthermore, global CMRglu in ADHDgirls was 19.6% lower than in ADHDboys (p = .02) and was not different between normal girls and normal boys. Clinical rating scales did not differentiate ADHDgirls from ADHDboys, nor normal girls from normal boys. CONCLUSIONS: The greater brain metabolism abnormalities in females than males strongly stress that more attention be given to the study of girls with ADHD.
Authors: Eve M Valera; Ariel Brown; Joseph Biederman; Stephen V Faraone; Nikos Makris; Michael C Monuteaux; Susan Whitfield-Gabrieli; Michael Vitulano; Michael Schiller; Larry J Seidman Journal: Am J Psychiatry Date: 2009-11-02 Impact factor: 18.112
Authors: Susan L Erickson; Anjalika R Gandhi; Josephine K Asafu-Adjei; Allan R Sampson; LeeAnn Miner; Randy D Blakely; Susan R Sesack Journal: Int J Neuropsychopharmacol Date: 2011-01-06 Impact factor: 5.176