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Literature DB >> 23907190

Linking HSCs to their youth.

Abstract

Fetal haematopoietic stem cells (HSCs) self-renew extensively to build the blood system from scratch. The protein Lin28b negatively regulates the microRNA let-7 to keep levels of its target Hmga2 high, hence conferring high self-renewal potential to fetal HSCs. This regulatory circuit can be experimentally modulated to boost the lower self-renewal activity of quiescent adult HSCs.

Entities: Gene

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Year: 2013 PMID： 23907190 DOI： 10.1038/ncb2817

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

13 in total

1. Relative to adult marrow, fetal liver repopulates nearly five times more effectively long-term than short-term.

Authors: D E Harrison; R K Zhong; C T Jordan; I R Lemischka; C M Astle
Journal: Exp Hematol Date: 1997-04 Impact factor: 3.084

2. Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells.

Authors: Injune Kim; Thomas L Saunders; Sean J Morrison
Journal: Cell Date: 2007-07-26 Impact factor: 41.582

3. Metabolic makeover for HSCs.

Authors: Matthew R Warr; Emmanuelle Passegué
Journal: Cell Stem Cell Date: 2013-01-03 Impact factor: 24.633

4. Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.

Authors: Keiyo Takubo; Go Nagamatsu; Chiharu I Kobayashi; Ayako Nakamura-Ishizu; Hiroshi Kobayashi; Eiji Ikeda; Nobuhito Goda; Yasmeen Rahimi; Randall S Johnson; Tomoyoshi Soga; Atsushi Hirao; Makoto Suematsu; Toshio Suda
Journal: Cell Stem Cell Date: 2013-01-03 Impact factor: 24.633

5. The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells.

Authors: Michael R Copley; Sonja Babovic; Claudia Benz; David J H F Knapp; Philip A Beer; David G Kent; Stefan Wohrer; David Q Treloar; Christopher Day; Keegan Rowe; Heidi Mader; Florian Kuchenbauer; R Keith Humphries; Connie J Eaves
Journal: Nat Cell Biol Date: 2013-06-30 Impact factor: 28.824

Review 6. The high mobility group protein HMGA2: a co-regulator of chromatin structure and pluripotency in stem cells?

Authors: Kurt Pfannkuche; Heike Summer; Ou Li; Jürgen Hescheler; Peter Dröge
Journal: Stem Cell Rev Rep Date: 2009-06-24 Impact factor: 5.739

7. Hematopoiesis: an evolving paradigm for stem cell biology.

Authors: Stuart H Orkin; Leonard I Zon
Journal: Cell Date: 2008-02-22 Impact factor: 41.582

Review 8. Lin28: primal regulator of growth and metabolism in stem cells.

Authors: Ng Shyh-Chang; George Q Daley
Journal: Cell Stem Cell Date: 2013-04-04 Impact factor: 24.633

9. C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence.

Authors: Min Ye; Hong Zhang; Giovanni Amabile; Henry Yang; Philipp B Staber; Pu Zhang; Elena Levantini; Meritxell Alberich-Jordà; Junyan Zhang; Akira Kawasaki; Daniel G Tenen
Journal: Nat Cell Biol Date: 2013-03-17 Impact factor: 28.824

10. Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression.

Authors: Jeffrey A Magee; Tsuneo Ikenoue; Daisuke Nakada; Jae Y Lee; Kun-Liang Guan; Sean J Morrison
Journal: Cell Stem Cell Date: 2012-09-07 Impact factor: 24.633

10 in total

Review 1. Impact of inflammation on early hematopoiesis and the microenvironment.

Authors: Hitoshi Takizawa; Markus G Manz
Journal: Int J Hematol Date: 2017-05-30 Impact factor: 2.490

2. Integrin α4-positive human trophoblast progenitors: functional characterization and transcriptional regulation.

Authors: O Genbacev; N Larocque; K Ona; A Prakobphol; T Garrido-Gomez; M Kapidzic; A Bárcena; M Gormley; S J Fisher
Journal: Hum Reprod Date: 2016-04-15 Impact factor: 6.918

3. Independent stem cell lineages regulate adipose organogenesis and adipose homeostasis.

Authors: Yuwei Jiang; Daniel C Berry; Wei Tang; Jonathan M Graff
Journal: Cell Rep Date: 2014-10-23 Impact factor: 9.423

4. Quantitative analysis of redox proteome reveals oxidation-sensitive protein thiols acting in fundamental processes of developmental hematopoiesis.

Authors: K Pimkova; M Jassinskaja; R Munita; M Ciesla; N Guzzi; P Cao Thi Ngoc; M Vajrychova; E Johansson; C Bellodi; J Hansson
Journal: Redox Biol Date: 2022-05-23 Impact factor: 10.787

5. Leucine-rich repeat-containing G-protein-coupled Receptor 5 marks short-term hematopoietic stem and progenitor cells during mouse embryonic development.

Authors: Donghua Liu; Xi C He; Pengxu Qian; Nick Barker; Paul A Trainor; Hans Clevers; Huiwen Liu; Linheng Li
Journal: J Biol Chem Date: 2014-06-25 Impact factor: 5.157

Review 10. The Mammalian High Mobility Group Protein AT-Hook 2 (HMGA2): Biochemical and Biophysical Properties, and Its Association with Adipogenesis.

Authors: Linjia Su; Zifang Deng; Fenfei Leng
Journal: Int J Mol Sci Date: 2020-05-25 Impact factor: 5.923