OBJECTIVES: Computed diffusion-weighted magnetic resonance imaging (cDWI) refers to the synthesizing of arbitrary b value diffusion-weighted images (DWI) from a set of measured b value images by voxelwise fitting. The objectives of this study were to quantitatively analyze the noise and the contrast-to-noise ratio (CNR) in cDWI as a function of b value by numerical simulations and by measurements in patients with prostate cancer and to compare cDWI to directly measured DWI at a b value of 1400 s/mm2. MATERIALS AND METHODS: Numerical simulations were performed to assess image noise and CNR in both cDWI and regular DWI. Forty-two patients with prostate cancer (age, 51-73 years; prostate specific antigen level, 0.5-30 ng/mL; and biopsy Gleason score, 6-9) received 2 DWI examinations at 3.0 T (one with b values of 100, 500, and 1400 s/mm2 and another with b values of 0, 100, 400, and 800 s/mm2) to create cDWI images at arbitrary b values, both with and without incorporating a b value of 0 s/mm2 in their calculation. Regions of interest were drawn to compare the scan time adjusted CNR (CNR eff) between cDWI and directly measured DWI at b = 1400 s/mm2 on tumor-suspicious lesions and normal-appearing regions. RESULTS: In the numerical simulations, noise depended strongly on the b value, the diffusion coefficient, and the signal intensity at a b value of 0 s/mm2 in cDWI but not in regular DWI. The CNR between simulated tumor and normal regions showed a continuous increase with increasing b value. Both these findings were also observed in tumor-suspicious and normal-appearing regions in in vivo data. In vivo prostate DWI at a b value of 1400 s/mm2 showed a similar CNR eff between the tumor-suspicious regions and the normal-appearing tissue in cDWI as in the directly measured DWI (P = 0.395). CONCLUSIONS: The CNR eff between tumor-suspicious and normal-appearing prostate tissue in DWI images at a b value of 1400 s/mm2 is comparable in cDWI and directly measured DWI. Computed DWI at even higher b values, calculated from measured images with b values between 0 and 800 s/mm2, yields higher CNR eff than measured DWI, which may be of clinical aid in the management of prostate cancer.
OBJECTIVES: Computed diffusion-weighted magnetic resonance imaging (cDWI) refers to the synthesizing of arbitrary b value diffusion-weighted images (DWI) from a set of measured b value images by voxelwise fitting. The objectives of this study were to quantitatively analyze the noise and the contrast-to-noise ratio (CNR) in cDWI as a function of b value by numerical simulations and by measurements in patients with prostate cancer and to compare cDWI to directly measured DWI at a b value of 1400 s/mm2. MATERIALS AND METHODS: Numerical simulations were performed to assess image noise and CNR in both cDWI and regular DWI. Forty-two patients with prostate cancer (age, 51-73 years; prostate specific antigen level, 0.5-30 ng/mL; and biopsy Gleason score, 6-9) received 2 DWI examinations at 3.0 T (one with b values of 100, 500, and 1400 s/mm2 and another with b values of 0, 100, 400, and 800 s/mm2) to create cDWI images at arbitrary b values, both with and without incorporating a b value of 0 s/mm2 in their calculation. Regions of interest were drawn to compare the scan time adjusted CNR (CNR eff) between cDWI and directly measured DWI at b = 1400 s/mm2 on tumor-suspicious lesions and normal-appearing regions. RESULTS: In the numerical simulations, noise depended strongly on the b value, the diffusion coefficient, and the signal intensity at a b value of 0 s/mm2 in cDWI but not in regular DWI. The CNR between simulated tumor and normal regions showed a continuous increase with increasing b value. Both these findings were also observed in tumor-suspicious and normal-appearing regions in in vivo data. In vivo prostate DWI at a b value of 1400 s/mm2 showed a similar CNR eff between the tumor-suspicious regions and the normal-appearing tissue in cDWI as in the directly measured DWI (P = 0.395). CONCLUSIONS: The CNR eff between tumor-suspicious and normal-appearing prostate tissue in DWI images at a b value of 1400 s/mm2 is comparable in cDWI and directly measured DWI. Computed DWI at even higher b values, calculated from measured images with b values between 0 and 800 s/mm2, yields higher CNR eff than measured DWI, which may be of clinical aid in the management of prostate cancer.
Authors: Y Ueno; S Takahashi; Y Ohno; K Kitajima; M Yui; Y Kassai; F Kawakami; H Miyake; K Sugimura Journal: Br J Radiol Date: 2015-01-21 Impact factor: 3.039
Authors: D Hausmann; N Aksöz; J von Hardenberg; T Martini; N Westhoff; S Buettner; S O Schoenberg; P Riffel Journal: Eur Radiol Date: 2017-08-10 Impact factor: 5.315
Authors: Kinzya B Grant; Harsh K Agarwal; Joanna H Shih; Marcelino Bernardo; Yuxi Pang; Dagane Daar; Maria J Merino; Bradford J Wood; Peter A Pinto; Peter L Choyke; Baris Turkbey Journal: Abdom Imaging Date: 2015-03
Authors: Yin Xi; Alexander Liu; Franklin Olumba; Parker Lawson; Daniel N Costa; Qing Yuan; Gaurav Khatri; Takeshi Yokoo; Ivan Pedrosa; Robert E Lenkinski Journal: Quant Imaging Med Surg Date: 2018-07