AIMS: The aim of this study was to evaluate the combined contribution of 12 genetic variants to the risk of coronary heart disease (CHD). METHODS: Through a comprehensive literature search for genetic variants involved in the CHD association study, we harvested a total of 10 genes (12 variants) for the current meta-analyses. These genes consisted of GPX1 (rs1050450), PPARD (rs2016520), ALOX15 (rs34210653), SELPLG (rs2228315), FCGR2A (rs1801274), CCL5 (rs2107538), CYP1A1 (rs4646903), TP53 (rs1042522), CX37 (rs1764391), and PECAM1 (rs668, rs12953, and rs1131012). RESULTS: A total of 45 studies among 23,314 cases and 28,430 controls were retrieved for the meta-analyses of 12 genetic variants. The results showed a significant association between the GPX1 rs1050450 polymorphism and CHD (odd ratio (OR)=1.61, 95% confidence interval (CI)=1.25-2.07, P=0.0002). Other meta-analyses of the rest 11 variants suggested a lack of association with the risk of CHD. CONCLUSION: Our results confirmed that GPX1 rs1050450 was associated with susceptibility to CHD in Chinese and Indian populations.
AIMS: The aim of this study was to evaluate the combined contribution of 12 genetic variants to the risk of coronary heart disease (CHD). METHODS: Through a comprehensive literature search for genetic variants involved in the CHD association study, we harvested a total of 10 genes (12 variants) for the current meta-analyses. These genes consisted of GPX1 (rs1050450), PPARD (rs2016520), ALOX15 (rs34210653), SELPLG (rs2228315), FCGR2A (rs1801274), CCL5 (rs2107538), CYP1A1 (rs4646903), TP53 (rs1042522), CX37 (rs1764391), and PECAM1 (rs668, rs12953, and rs1131012). RESULTS: A total of 45 studies among 23,314 cases and 28,430 controls were retrieved for the meta-analyses of 12 genetic variants. The results showed a significant association between the GPX1rs1050450 polymorphism and CHD (odd ratio (OR)=1.61, 95% confidence interval (CI)=1.25-2.07, P=0.0002). Other meta-analyses of the rest 11 variants suggested a lack of association with the risk of CHD. CONCLUSION: Our results confirmed that GPX1rs1050450 was associated with susceptibility to CHD in Chinese and Indian populations.
Authors: Long H Ngo; M Austin Argentieri; Simon T Dillon; Blake Victor Kent; Alka M Kanaya; Alexandra E Shields; Towia A Libermann Journal: Sci Rep Date: 2021-01-13 Impact factor: 4.379