RATIONALE: It is hypothesized that the metabolic syndrome explains the association between body mass index (BMI) and asthma in adults. OBJECTIVES: Our objective was to longitudinally compare the relative strengths of the associations of the metabolic syndrome and BMI with incident asthma in adults. METHODS: We included 4,619 eligible participants in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort followed over 25 years. Incident asthma was defined by a new self-reported provider asthma diagnosis plus either the presence of asthma symptoms and/or use of asthma medications. Cox proportional hazard analyses were performed. MEASUREMENTS AND MAIN RESULTS:Six hundred two subjects (417 women and 185 men) developed incident asthma over 25 years of follow-up. Metabolic syndrome predicted incident asthma among women but not men (unadjusted hazard ratios, 1.50 and 0.98; P = 0.01 and 0.93, respectively). BMI had a similar predictive association among women but not men (unadjusted hazard ratios, 1.19 and 1.04 per 5 units of BMI; P < 0.001 and 0.60, respectively). The association of metabolic syndrome with incident asthma in women was no longer statistically significant after adjustment for BMI (P = 0.44). In contrast, the association of BMI with incident asthma in women remained statistically significant after adjusting for the metabolic syndrome (P = 0.01). In a stepwise model, BMI was a stronger predictor than the metabolic syndrome (P = 0.001). CONCLUSIONS: BMI is a stronger predictor of incident asthma among women than the metabolic syndrome. Other obesity-associated factors that are not a part of the metabolic syndrome may play a role in the BMI-asthma association in women.
RCT Entities:
RATIONALE: It is hypothesized that the metabolic syndrome explains the association between body mass index (BMI) and asthma in adults. OBJECTIVES: Our objective was to longitudinally compare the relative strengths of the associations of the metabolic syndrome and BMI with incident asthma in adults. METHODS: We included 4,619 eligible participants in the Coronary Artery Risk Development in Young Adults (CARDIA) cohort followed over 25 years. Incident asthma was defined by a new self-reported provider asthma diagnosis plus either the presence of asthma symptoms and/or use of asthma medications. Cox proportional hazard analyses were performed. MEASUREMENTS AND MAIN RESULTS: Six hundred two subjects (417 women and 185 men) developed incident asthma over 25 years of follow-up. Metabolic syndrome predicted incident asthma among women but not men (unadjusted hazard ratios, 1.50 and 0.98; P = 0.01 and 0.93, respectively). BMI had a similar predictive association among women but not men (unadjusted hazard ratios, 1.19 and 1.04 per 5 units of BMI; P < 0.001 and 0.60, respectively). The association of metabolic syndrome with incident asthma in women was no longer statistically significant after adjustment for BMI (P = 0.44). In contrast, the association of BMI with incident asthma in women remained statistically significant after adjusting for the metabolic syndrome (P = 0.01). In a stepwise model, BMI was a stronger predictor than the metabolic syndrome (P = 0.001). CONCLUSIONS: BMI is a stronger predictor of incident asthma among women than the metabolic syndrome. Other obesity-associated factors that are not a part of the metabolic syndrome may play a role in the BMI-asthma association in women.
Authors: Claudia R Morris; Mirjana Poljakovic; Lisa Lavrisha; Lorenzo Machado; Frans A Kuypers; Sidney M Morris Journal: Am J Respir Crit Care Med Date: 2004-04-07 Impact factor: 21.405
Authors: Akshay Sood; Clifford Qualls; Mark Schuyler; Bharat Thyagarajan; Michael W Steffes; Lewis J Smith; David R Jacobs Journal: Am J Respir Crit Care Med Date: 2012-04-06 Impact factor: 21.405
Authors: G R Cutter; G L Burke; A R Dyer; G D Friedman; J E Hilner; G H Hughes; S B Hulley; D R Jacobs; K Liu; T A Manolio Journal: Control Clin Trials Date: 1991-02
Authors: Anne E Dixon; Emmanuelle M Clerisme-Beaty; Elizabeth A Sugar; Rubin I Cohen; Jason E Lang; Ellen D Brown; Joel E Richter; Charles G Irvin; John G Mastronarde Journal: J Asthma Date: 2011-08-08 Impact factor: 2.515
Authors: Cynthia W Baffi; Lisa Wood; Daniel Winnica; Patrick J Strollo; Mark T Gladwin; Loretta G Que; Fernando Holguin Journal: Chest Date: 2016-01-20 Impact factor: 9.410
Authors: W Gerald Teague; Brenda R Phillips; John V Fahy; Sally E Wenzel; Anne M Fitzpatrick; Wendy C Moore; Annette T Hastie; Eugene R Bleecker; Deborah A Meyers; Stephen P Peters; Mario Castro; Andrea M Coverstone; Leonard B Bacharier; Ngoc P Ly; Michael C Peters; Loren C Denlinger; Sima Ramratnam; Ronald L Sorkness; Benjamin M Gaston; Serpil C Erzurum; Suzy A A Comhair; Ross E Myers; Joe Zein; Mark D DeBoer; Anne-Marie Irani; Elliot Israel; Bruce Levy; Juan Carlos Cardet; Wanda Phipatanakul; Jonathan M Gaffin; Fernando Holguin; Merritt L Fajt; Shean J Aujla; David T Mauger; Nizar N Jarjour Journal: J Allergy Clin Immunol Pract Date: 2017-08-31
Authors: Karamarie Fecho; Stanley C Ahalt; Saravanan Arunachalam; James Champion; Christopher G Chute; Sarah Davis; Kenneth Gersing; Gustavo Glusman; Jennifer Hadlock; Jewel Lee; Emily Pfaff; Max Robinson; Eric Sid; Casey Ta; Hao Xu; Richard Zhu; Qian Zhu; David B Peden Journal: J Biomed Inform Date: 2019-10-30 Impact factor: 6.317