Literature DB >> 23904389

Lipid pools as photolabile "protecting groups": design of light-activatable bioagents.

Luong T Nguyen1, Nathan P Oien, Nancy L Allbritton, David S Lawrence.   

Abstract

Inactive in the membrane: Lipidated light-responsive constructs that sequester bioagents (R, see scheme) to the membranes of organelles and cells have been constructed. When membrane-bound, the bioagent is not susceptible to processing by its biological target. Photolysis releases the bioagent from its membrane anchor and thereby renders it biologically active.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  biosensors; cell adhesion; fluorescent probes; phosphorylation; photolysis

Mesh：

Substances：

Year:  2013        PMID： 23904389      PMCID： PMC3840492          DOI： 10.1002/anie.201305510

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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