Literature DB >> 19648933

Membrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation.

Amanda Cobos-Correa1, Johanna B Trojanek, Stefanie Diemer, Marcus A Mall, Carsten Schultz.   

Abstract

MMP12 is a metalloproteinase implicated in inflammation. To monitor its activity, we synthesized a membrane-targeted reporter (LaRee1) based on Foerster resonance energy transfer (FRET). Unlike existing sensors, LaRee1 detects MMP12 activity by loss of FRET plus internalization of the lipidated fragment. In bronchoalveolar lavages from a mouse model of pulmonary inflammation, LaRee1 detected MMP12 activity at the surface of activated macrophages. LaRee1 may become a powerful tool for monitoring lung disease.

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Year:  2009        PMID： 19648933     DOI： 10.1038/nchembio.196

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  21 in total

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  33 in total

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