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Literature DB >> 23904331

The role of water and sodium ions in the activation of the μ-opioid receptor.

Shuguang Yuan¹, Horst Vogel, Slawomir Filipek.

Abstract

Dual effect of sodium ions: The activation of G-protein-coupled receptors depends on the presence of water molecules inside the receptor and also on allosteric interactions. The binding of sodium ions to the allosteric site of the μ opioid receptor was studied by microsecond molecular dynamics simulations and their seemingly contradictory roles in preventing ligand binding and facilitating receptor activation were explained.

Entities: Chemical

Keywords: G-protein-coupled receptors; activation mechanisms; activation switches; opioid receptor; sodium ions

Mesh：

Substances：

Year: 2013 PMID： 23904331 DOI： 10.1002/anie.201302244

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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Cited

40 in total

1. Allosteric effects of sodium ion binding on activation of the m3 muscarinic g-protein-coupled receptor.

Authors: Yinglong Miao; Alisha D Caliman; J Andrew McCammon
Journal: Biophys J Date: 2015-04-07 Impact factor: 4.033

Review 2. Modulation of GPCRs by monovalent cations and anions.

Authors: Andrea Strasser; Hans-Joachim Wittmann; Erich H Schneider; Roland Seifert
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2014-11-30 Impact factor: 3.000

Review 3. Insights into the function of opioid receptors from molecular dynamics simulations of available crystal structures.

Authors: Kristen A Marino; Yi Shang; Marta Filizola
Journal: Br J Pharmacol Date: 2017-04-12 Impact factor: 8.739

4. Allosteric sodium in class A GPCR signaling.

Authors: Vsevolod Katritch; Gustavo Fenalti; Enrique E Abola; Bryan L Roth; Vadim Cherezov; Raymond C Stevens
Journal: Trends Biochem Sci Date: 2014-04-21 Impact factor: 13.807

5. G protein-coupled receptors of class A harness the energy of membrane potential to increase their sensitivity and selectivity.

Authors: Daria N Shalaeva; Dmitry A Cherepanov; Michael Y Galperin; Gert Vriend; Armen Y Mulkidjanian
Journal: Biochim Biophys Acta Biomembr Date: 2019-08-23 Impact factor: 3.747

The role of water and sodium ions in the activation of the μ-opioid receptor.

1. Allosteric effects of sodium ion binding on activation of the m3 muscarinic g-protein-coupled receptor.

Review 2. Modulation of GPCRs by monovalent cations and anions.

Review 3. Insights into the function of opioid receptors from molecular dynamics simulations of available crystal structures.

4. Allosteric sodium in class A GPCR signaling.

5. G protein-coupled receptors of class A harness the energy of membrane potential to increase their sensitivity and selectivity.

6. Structural basis for ligand modulation of the CCR2 conformational landscape.

7. Molecular dynamics of fentanyl bound to μ-opioid receptor.

8. Sodium binding to hH3R and hH 4R--a molecular modeling study.

9. Ultraslow Water-Mediated Transmembrane Interactions Regulate the Activation of A2A Adenosine Receptor.

10. Deciphering collaborative sidechain motions in proteins during molecular dynamics simulations.