Literature DB >> 2390088

Molecular cloning of guinea-pig aromatic-L-amino acid decarboxylase cDNA.

M Taketoshi1, Y Horio, I Imamura, T Tanaka, H Fukui, H Wada.   

Abstract

Guinea-pig aromatic-L-amino acid decarboxylase (DOPA decarboxylase, DDC), but not rat DDC, reacts with the antibody against rat histidine decarboxylase (HDC). For determination of the molecular reaction for this cross-reactivity, a cDNA clone of guinea-pig DDC was isolated. Guinea-pig DDC consists of 480 amino acids and its molecular weight is 54,148. The sequence identify of guinea-pig DDC with rat DDC is 86%. Guinea-pig DDC has a region showing 100% sequence identity with rat HDC, but only 67% sequence identity with rat DDC, suggesting that this region is related with the cross-reactivity of guinea-pig DDC and anti-rat HDC antibody.

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Year:  1990        PMID： 2390088     DOI： 10.1016/0006-291x(90)90525-r

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  3 in total

1.  Cloning and expression of pig kidney dopa decarboxylase: comparison of the naturally occurring and recombinant enzymes.

Authors:  P S Moore; P Dominici; C Borri Voltattorni
Journal:  Biochem J       Date:  1996-04-01       Impact factor: 3.857

2.  Mutation of cysteine 111 in Dopa decarboxylase leads to active site perturbation.

Authors:  P Dominici; P S Moore; S Castellani; M Bertoldi; C B Voltattorni
Journal:  Protein Sci       Date:  1997-09       Impact factor: 6.725

3.  Assignment of the rat genes coding for dopa decarboxylase (DDC) and glutamic acid decarboxylases (GAD1 and GAD2).

Authors:  C Vassort; M Rivière; G Bruneau; F Gros; J Thibault; G Levan; J Szpirer; C Szpirer
Journal:  Mamm Genome       Date:  1993       Impact factor: 2.957
  3 in total

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