Literature DB >> 23896471

Clotrimazole dampens vaginal inflammation and neutrophil infiltration in response to Candida albicans infection.

Duncan Wilson1, Betty Hebecker, David L Moyes, Pedro Miramón, Nadja Jablonowski, Stephanie Wisgott, Stefanie Allert, Julian R Naglik, Bernhard Hube.   

Abstract

The pathology of vulvovaginal candidiasis (VVC) caused by Candida albicans is associated with a nonprotective inflammatory response and is frequently treated with clotrimazole. We investigated the mechanisms by which clotrimazole resolves VVC. Low levels of clotrimazole, which do not block fungal growth, inhibit expression of a "danger response" transcription factor, c-Fos, block production of proinflammatory cytokines, and inhibit neutrophil infiltration to the site of infection.

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Year:  2013        PMID： 23896471      PMCID： PMC3811401          DOI： 10.1128/AAC.01244-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

Review 1.  Cytokines in the host response to Candida vaginitis: Identifying a role for non-classical immune mediators, S100 alarmins.

Authors:  Junko Yano; Mairi C Noverr; Paul L Fidel
Journal:  Cytokine       Date:  2011-12-17       Impact factor: 3.861

2.  Candida albicans adhesion to and invasion and damage of vaginal epithelial cells: stage-specific inhibition by clotrimazole and bifonazole.

Authors:  Betty Wächtler; Duncan Wilson; Bernhard Hube
Journal:  Antimicrob Agents Chemother       Date:  2011-07-11       Impact factor: 5.191

3.  Epithelial cell-derived S100 calcium-binding proteins as key mediators in the hallmark acute neutrophil response during Candida vaginitis.

Authors:  Junko Yano; Elizabeth Lilly; Melissa Barousse; Paul L Fidel
Journal:  Infect Immun       Date:  2010-09-07       Impact factor: 3.441

4.  Induction of ERK-kinase signalling triggers morphotype-specific killing of Candida albicans filaments by human neutrophils.

Authors:  Iwona Wozniok; Anke Hornbach; Corinna Schmitt; Matthias Frosch; Hermann Einsele; Bernhard Hube; Jürgen Löffler; Oliver Kurzai
Journal:  Cell Microbiol       Date:  2007-11-21       Impact factor: 3.715

Review 5.  Vulvovaginal candidosis.

Authors:  Jack D Sobel
Journal:  Lancet       Date:  2007-06-09       Impact factor: 79.321

Review 6.  Nosocomial fungal infections: epidemiology, diagnosis, and treatment.

Authors:  Joshua Perlroth; Bryan Choi; Brad Spellberg
Journal:  Med Mycol       Date:  2007-06       Impact factor: 4.076

7.  Clotrimazole ameliorates intestinal inflammation and abnormal angiogenesis by inhibiting interleukin-8 expression through a nuclear factor-kappaB-dependent manner.

Authors:  Dinesh Thapa; Jong Suk Lee; Su-Young Park; Yun-Hee Bae; Soo-Kyung Bae; Jun Bum Kwon; Kyoung-Jin Kim; Mi-Kyoung Kwak; Young-Joon Park; Han Gon Choi; Jung-Ae Kim
Journal:  J Pharmacol Exp Ther       Date:  2008-08-26       Impact factor: 4.030

8.  A biphasic innate immune MAPK response discriminates between the yeast and hyphal forms of Candida albicans in epithelial cells.

Authors:  David L Moyes; Manohursingh Runglall; Celia Murciano; Chengguo Shen; Deepa Nayar; Selvam Thavaraj; Arinder Kohli; Ayesha Islam; Hector Mora-Montes; Stephen J Challacombe; Julian R Naglik
Journal:  Cell Host Microbe       Date:  2010-09-16       Impact factor: 21.023

9.  From attachment to damage: defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells.

Authors:  Betty Wächtler; Duncan Wilson; Katja Haedicke; Frederic Dalle; Bernhard Hube
Journal:  PLoS One       Date:  2011-02-23       Impact factor: 3.240

10.  Candida albicans yeast and hyphae are discriminated by MAPK signaling in vaginal epithelial cells.

Authors:  David L Moyes; Celia Murciano; Manohursingh Runglall; Ayesha Islam; Selvam Thavaraj; Julian R Naglik
Journal:  PLoS One       Date:  2011-11-08       Impact factor: 3.240
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  2 in total

1.  Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses.

Authors:  Frank H Robledo-Avila; Juan de Dios Ruiz-Rosado; Kenneth L Brockman; Benjamin T Kopp; Amal O Amer; Karen McCoy; Lauren O Bakaletz; Santiago Partida-Sanchez
Journal:  J Immunol       Date:  2018-08-17       Impact factor: 5.422

2.  Clotrimazole Fluidizes Phospholipid Membranes and Localizes at the Hydrophobic Part near the Polar Part of the Membrane.

Authors:  Alessio Ausili; Illya Yakymenko; José A Teruel; Juan C Gómez-Fernández
Journal:  Biomolecules       Date:  2021-09-02
  2 in total

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