| Literature DB >> 23895999 |
Jae Yeon Kim1, Hwanbum Lee, Keun Sang Oh, Seho Kweon, Ok-cheol Jeon, Youngro Byun, Kwangmeyung Kim, Ick Chan Kwon, Sang Yoon Kim, Soon Hong Yuk.
Abstract
A method for the sustained delivery of exenatide was proposed using nanoparticles (NPs) with a core/shell structure. The interactions between lipid bilayers and Pluronics were utilized to form various NPs using a layer-by-layer approach. Transmittance electron microscopy and dynamic light scattering were used to examine the morphology of the NPs. The in vitro release pattern was observed as a function of changes in the structure of the NPs, and the structural integrity of exenatide released was examined by SDS-PAGE analysis. Pharmacokinetics and antidiabetic effects were also observed with the structural change of NPs using in vivo animal models. In vitro-in vivo correlation was discussed in relation to manipulation of the NP structures.Entities:
Keywords: Core/shell nanoparticles; Layer-by-layer approach; Lipid bilayers; Pluronics; Sustained delivery of exenatide
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Year: 2013 PMID： 23895999 DOI： 10.1016/j.biomaterials.2013.07.040
Source DB: PubMed Journal: Biomaterials ISSN： 0142-9612 Impact factor: 12.479