| Literature DB >> 23893866 |
Katherine A Moga1, Lissett R Bickford, Robert D Geil, Stuart S Dunn, Ashish A Pandya, Yapei Wang, John H Fain, Christine F Archuleta, Adrian T O'Neill, Joseph M Desimone.
Abstract
Microneedle devices for transdermal drug delivery have recently become an attractive method to overcome the diffusion-limiting epidermis and effectively transport therapeutics to the body. Here, we demonstrate the fabrication of highly reproducible and completely dissolvable polymer microneedles on flexible water-soluble substrates. These biocompatible microneedles (made by using a soft lithography process known as PRINT) showed efficacy in piercing both murine and human skin samples and delivering a fluorescent drug surrogate to the tissue.Entities:
Keywords: PRINT; drug delivery; microneedles; microprojections; soft lithography
Year: 2013 PMID: 23893866 PMCID: PMC4262250 DOI: 10.1002/adma.201300526
Source DB: PubMed Journal: Adv Mater ISSN: 0935-9648 Impact factor: 30.849