Muhammad Sohail Arshad1, Sana Hassan1, Amjad Hussain2, Nasir Abbas2, Israfil Kucuk3, Kazem Nazari4, Radeyah Ali4, Suleman Ramzan4, Ali Alqahtani4, Eleftherios G Andriotis5, Dimitris G Fatouros5, Ming-Wei Chang6,7,8, Zeeshan Ahmad9. 1. Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan. 2. College of Pharmacy, University of the Punjab Lahore, Lahore, Pakistan. 3. Faculty of Engineering and natural sciences, Bursa Technical University, Bursa, Turkey. 4. The Leicester School of Pharmacy, De Montfort University, Leicester, UK. 5. Department of Pharmacy, Aristotle University of Thessaloniki, Thessaloniki, Greece. 6. Department of Biomedical Engineering, Key Laboratory of Ministry of Education, Zhejiang University, Hangzhou, 310027, People's Republic of China. 7. Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, 310027, People's Republic of China. 8. Nanotechnology and Integrated Bioengineering Centre, University of Ulster, Jordanstown Campus, Newtownabbey, Northern Ireland, BT37 0QB, UK. 9. The Leicester School of Pharmacy, De Montfort University, Leicester, UK. zeeshan.ahmad@dmu.ac.uk.
Abstract
PURPOSE: The aim of this study was to design and characterize microneedle patch formulation containing cetirizine hydrochloride. METHODS: Chitosan was co-formulated with cetirizine hydrochloride. Transdermal patches were prepared by casting this solution to microneedle molds. Control patches were formulated by casting this solution to a plain cuvet of same area as mold but lacking microneedles. An array of methods namely; differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM) were employed for the characterization of the films and the microneedles accordingly whereas in vitro permeation studies were conducted across rat skin. Light microscopy was performed to assess any histological changes upon microneedles application onto the rat skin. RESULTS: The patches had a reproducible thickness (0.86 ± 0.06 mm) and folding endurance. Both the blank and drug loaded patches had 100 microneedles each of 300 micrometre length. In addition, the microneedle patches were ascribed with a two-fold increase in drug permeation across rat skin in the presence of microneedles as compared to the control formulations. Histological examination confirms a minimal invasion of the skin conferred by the microneedles. CONCLUSION: The microneedle patches serve as an alternate route of drug administration in patients with nausea and swelling difficulties. Graphical abstract Microneedle patch manifest a two-fold increase in the skin permeation of Cetirizine Hydrochloride as compared to the control that is drug loaded patch without microneedles.
PURPOSE: The aim of this study was to design and characterize microneedle patch formulation containing cetirizine hydrochloride. METHODS: Chitosan was co-formulated with cetirizine hydrochloride. Transdermal patches were prepared by casting this solution to microneedle molds. Control patches were formulated by casting this solution to a plain cuvet of same area as mold but lacking microneedles. An array of methods namely; differential scanning calorimetry (DSC), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM) were employed for the characterization of the films and the microneedles accordingly whereas in vitro permeation studies were conducted across rat skin. Light microscopy was performed to assess any histological changes upon microneedles application onto the rat skin. RESULTS: The patches had a reproducible thickness (0.86 ± 0.06 mm) and folding endurance. Both the blank and drug loaded patches had 100 microneedles each of 300 micrometre length. In addition, the microneedle patches were ascribed with a two-fold increase in drug permeation across rat skin in the presence of microneedles as compared to the control formulations. Histological examination confirms a minimal invasion of the skin conferred by the microneedles. CONCLUSION: The microneedle patches serve as an alternate route of drug administration in patients with nausea and swelling difficulties. Graphical abstract Microneedle patch manifest a two-fold increase in the skin permeation of Cetirizine Hydrochloride as compared to the control that is drug loaded patch without microneedles.
Entities:
Keywords:
Cetirizine Hydrochloride; Microneedles; Transdermal Drug delivery
Authors: Hendrik F van Essen; Marina A M Verdaasdonk; Sabrina M Elshof; Roel A de Weger; Paul J van Diest Journal: J Clin Pathol Date: 2010-10-26 Impact factor: 3.411
Authors: Manoochehr Rasekh; Christina Karavasili; Yi Ling Soong; Nikolaos Bouropoulos; Mhairi Morris; David Armitage; Xiang Li; Dimitrios G Fatouros; Zeeshan Ahmad Journal: Int J Pharm Date: 2014-07-02 Impact factor: 5.875
Authors: Sharif Abdelghany; Walhan Alshaer; Yazan Al Thaher; Maram Al Fawares; Amal G Al-Bakri; Saja Zuriekat; Randa Sh Mansour Journal: Beilstein J Nanotechnol Date: 2022-06-15 Impact factor: 3.272