Literature DB >> 23893382

CARMA3 is overexpressed in human glioma and promotes cell invasion through MMP9 regulation in A172 cell line.

Xingjun Feng1, Guozhuan Miao, Yipeng Han, Yi Xu.   

Abstract

Caspase recruitment domain-containing membrane-associated guanylate kinase protein 10 or CARMA3 (CARD10) is a recently characterized oncoprotein involved in the progression of several human malignancies. The present study aims to investigate the expression pattern and biological roles of CARMA3 protein in human glioma. CARMA3 expression was analyzed in 97 glioma specimens using immunohistochemistry. We observed negative staining in normal astrocytes and positive staining of CARMA3 in 25 out of 97 (25.8%) glioma samples. Overexpression of CARMA3 correlated with tumor grade (p < 0.001). Small interfering RNA knockdown was performed in A172 cell line with relatively high CARMA3 expression. Using colony formation assay and Matrigel invasion assay, we showed that CARMA3 depletion in A172 cell line inhibited cell proliferation and cell invasion. In addition, mRNA and protein levels of matrix metallopeptidase 9 (MMP9) were downregulated, indicating CARMA3 might regulate invasion through MMP9. In conclusion, CARMA3 serves as an oncoprotein in human glioma by regulating cell invasion, possibly through MMP9 regulation.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 23893382     DOI： 10.1007/s13277-013-1018-2

Source DB:  PubMed          Journal:  Tumour Biol        ISSN： 1010-4283


  24 in total

1.  Bimp1, a MAGUK family member linking protein kinase C activation to Bcl10-mediated NF-kappaB induction.

Authors:  L M McAllister-Lucas; N Inohara; P C Lucas; J Ruland; A Benito; Q Li; S Chen; F F Chen; S Yamaoka; I M Verma; T W Mak; G Núñez
Journal:  J Biol Chem       Date:  2001-05-31       Impact factor: 5.157

2.  CARMA3: A novel scaffold protein in regulation of NF-κB activation and diseases.

Authors:  Jiyuan Sun
Journal:  World J Biol Chem       Date:  2010-12-26

3.  CARMA3/Bcl10/MALT1-dependent NF-kappaB activation mediates angiotensin II-responsive inflammatory signaling in nonimmune cells.

Authors:  Linda M McAllister-Lucas; Jürgen Ruland; Katy Siu; Xiaohong Jin; Shufang Gu; David S L Kim; Peter Kuffa; Dawn Kohrt; Tak W Mak; Gabriel Nuñez; Peter C Lucas
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-13       Impact factor: 11.205

4.  Culture of human breast cancer cell line (MDA-MB-231) on fibronectin-coated surface induces pro-matrix metalloproteinase-9 expression and activity.

Authors:  Gargi Maity; Paromita Roy Choudhury; Triparna Sen; Kirat Kumar Ganguly; Hrishikesh Sil; Amitava Chatterjee
Journal:  Tumour Biol       Date:  2010-09-07

5.  Tumor necrosis factor-related weak inducer of apoptosis augments matrix metalloproteinase 9 (MMP-9) production in skeletal muscle through the activation of nuclear factor-kappaB-inducing kinase and p38 mitogen-activated protein kinase: a potential role of MMP-9 in myopathy.

Authors:  Hong Li; Ashwani Mittal; Pradyut K Paul; Mukesh Kumar; Daya S Srivastava; Suresh C Tyagi; Ashok Kumar
Journal:  J Biol Chem       Date:  2008-12-11       Impact factor: 5.157

6.  Microarray analyses of the effects of NF-kappaB or PI3K pathway inhibitors on the LPS-induced gene expression profile in RAW264.7 cells: synergistic effects of rapamycin on LPS-induced MMP9-overexpression.

Authors:  Sofia Dos Santos Mendes; Aurélie Candi; Martine Vansteenbrugge; Marie-Rose Pignon; Hidde Bult; Karim Zouaoui Boudjeltia; Carine Munaut; Martine Raes
Journal:  Cell Signal       Date:  2009-03-12       Impact factor: 4.315

7.  CARMA3 is overexpressed in colon cancer and regulates NF-κB activity and cyclin D1 expression.

Authors:  Zhifeng Miao; Tingting Zhao; Zhenning Wang; Yingying Xu; Yongxi Song; Jianhua Wu; Huimian Xu
Journal:  Biochem Biophys Res Commun       Date:  2012-08-02       Impact factor: 3.575

8.  CARMA3 overexpression accelerates cell proliferation and inhibits paclitaxel-induced apoptosis through NF-κB regulation in breast cancer cells.

Authors:  Tingting Zhao; Zhifeng Miao; Zhenning Wang; Yingying Xu; Jianhua Wu; Xingyu Liu; Yi You; Jiguang Li
Journal:  Tumour Biol       Date:  2013-05-25

9.  Overexpression of CARMA3 in non-small-cell lung cancer is linked for tumor progression.

Authors:  Zixuan Li; Lianyue Qu; Qianze Dong; Bo Huang; Haiying Li; Zhongping Tang; Ying Xu; Wenting Luo; Lifeng Liu; Xueshan Qiu; Enhua Wang
Journal:  PLoS One       Date:  2012-05-15       Impact factor: 3.240

10.  Bmi-1 promotes the aggressiveness of glioma via activating the NF-kappaB/MMP-9 signaling pathway.

Authors:  Lili Jiang; Jueheng Wu; Yi Yang; Liping Liu; Libing Song; Jun Li; Mengfeng Li
Journal:  BMC Cancer       Date:  2012-09-11       Impact factor: 4.430
View more
  13 in total

1.  LRRC3B is downregulated in non-small-cell lung cancer and inhibits cancer cell proliferation and invasion.

Authors:  Liang Kan; Hui Li; Yi Zhang; Jiahe Wang; Huiyan Niu; Hongfang Jiang; Meng Zhang; Xue Bai; Ping He
Journal:  Tumour Biol       Date:  2015-08-15

2.  HCRP1 is downregulated in non-small cell lung cancer and regulates proliferation, invasion, and drug resistance.

Authors:  Yaming Du; Peng Wang; Hongzhi Sun; Jing Yang; Xianping Lang; Zhongbin Wang; Sheng Zang; Lei Chen; Junjun Ma; Daohan Sun
Journal:  Tumour Biol       Date:  2016-10-13

3.  CARMA3 is upregulated in human pancreatic carcinoma, and its depletion inhibits tumor proliferation, migration, and invasion.

Authors:  Shiyu Du; Liping Jia; Yanli Zhang; Long Fang; Xiang Zhang; Yanhua Fan
Journal:  Tumour Biol       Date:  2014-03-16

4.  MiRNA-181c inhibits EGFR-signaling-dependent MMP9 activation via suppressing Akt phosphorylation in glioblastoma.

Authors:  Fei Wang; Weizhong Xiao; Jiyong Sun; Donghua Han; Youhou Zhu
Journal:  Tumour Biol       Date:  2014-05-28

5.  CrkL regulates SDF-1-induced breast cancer biology through balancing Erk1/2 and PI3K/Akt pathways.

Authors:  Xin Lian; Yu Jiao; Yu Yang; Zhipeng Wang; Qijia Xuan; Hang Liu; Shan Lu; Zunxian Wang; Yue Liu; Shuo Li; Yuguang Yang; Li Guo; Ling Zhao; Qingyuan Zhang
Journal:  Med Oncol       Date:  2014-12-05       Impact factor: 3.064

6.  RASSF4 is downregulated in nonsmall cell lung cancer and inhibits cancer cell proliferation and invasion.

Authors:  Yong Han; Qianze Dong; Jie Hao; Lin Fu; Xu Han; Xiaoying Zheng; Enhua Wang
Journal:  Tumour Biol       Date:  2015-11-02

7.  MMP9 activation triggered by epidermal growth factor induced FoxO1 nuclear exclusion in non-small cell lung cancer.

Authors:  Jun Pei; Yuqing Lou; Runbo Zhong; Baohui Han
Journal:  Tumour Biol       Date:  2014-04-06

8.  Overexpression of CARMA3 is associated with advanced tumor stage, cell cycle progression, and cisplatin resistance in human epithelial ovarian cancer.

Authors:  Chengyao Xie; Yong Han; Lin Fu; Qingchang Li; Xueshan Qiu; Enhua Wang
Journal:  Tumour Biol       Date:  2014-05-16

9.  [LRRC3B is Downregulated in Non-small Cell Lung Cancer and Connected with Cell Proliferation and Invasion].

Authors:  Liang Kan; Meng Zhang; Ping He
Journal:  Zhongguo Fei Ai Za Zhi       Date:  2016-04-20

10.  Silencing of CARMA3 inhibits bladder cancer cell migration and invasion via deactivating β-catenin signaling pathway.

Authors:  Xiaojun Man; Tao Liu; Yuanjun Jiang; Zhe Zhang; Yuyan Zhu; Zhenhua Li; Chuize Kong; Jiani He
Journal:  Onco Targets Ther       Date:  2019-08-09       Impact factor: 4.147
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.