PURPOSE: MicroRNAs (miRNAs) are small endogenous, non-coding, single-stranded RNAs (approximately 22 nt). Accumulating evidence has shown that aberrant miRNA expression is pronounced and correlated with gastric cancer genesis and progression. MATERIALS AND METHODS: Expression levels of miR-181a-5p in GC tissues and cell lines were assessed by qRT-PCR and tested for correlation with clinical features. In addition, effects of miR-181a-5p on GC cell growth were investigated. RESULTS: Our findings indicate that miR-181a-5p is upregulated in GC, in correlation with lymph node invasion, nerve invasion and vascular invasion (P<0.05). Enforced expression of miR-181a -5p promoted cell proliferation ability. CONCLUSIONS: This study suggested that increased miR-181a-5p is related to GC progression. MiR-181a-5p may represent a potential therapeutic target for GC.
PURPOSE: MicroRNAs (miRNAs) are small endogenous, non-coding, single-stranded RNAs (approximately 22 nt). Accumulating evidence has shown that aberrant miRNA expression is pronounced and correlated with gastric cancer genesis and progression. MATERIALS AND METHODS: Expression levels of miR-181a-5p in GC tissues and cell lines were assessed by qRT-PCR and tested for correlation with clinical features. In addition, effects of miR-181a-5p on GC cell growth were investigated. RESULTS: Our findings indicate that miR-181a-5p is upregulated in GC, in correlation with lymph node invasion, nerve invasion and vascular invasion (P<0.05). Enforced expression of miR-181a -5p promoted cell proliferation ability. CONCLUSIONS: This study suggested that increased miR-181a-5p is related to GC progression. MiR-181a-5p may represent a potential therapeutic target for GC.
Authors: Johannes Neu; Piotr Jan Dziunycz; Andreas Dzung; Karine Lefort; Martin Falke; Rémy Denzler; Sandra Nicole Freiberger; Guergana Iotzova-Weiss; Aleksandar Kuzmanov; Mitchell Paul Levesque; Gian-Paolo Dotto; Günther Franz L Hofbauer Journal: PLoS One Date: 2017-09-20 Impact factor: 3.240
Authors: Vincent A Funari; Michael Winkler; Jordan Brown; Slobodan D Dimitrijevich; Alexander V Ljubimov; Mehrnoosh Saghizadeh Journal: PLoS One Date: 2013-12-20 Impact factor: 3.240