PURPOSE: Little is known about risk factors for pregnancy-associated breast cancer (PABC), diagnosed during pregnancy or postpartum. METHODS: We enrolled 1715 premenopausal women from the Nigerian Breast Cancer Study from 1998 to 2011. Based on recency of last pregnancy from diagnosis, breast cancer cases were categorized as (1) PABC diagnosed 2 years or longer postpartum, (2) PABC diagnosed 3 to 5 years postpartum, or (3) non-PABC diagnosed more than 5 years postpartum. Controls were matched to cases on recency of last pregnancy. Multiple logistic regressions were performed comparing cases and controls within each group. RESULTS: Of the 718 cases, 152 (21.2%) had PABC 2 or more years postpartum, and 145 (20.2%) 3 to 5 years postpartum. Although not statistically significant, women with higher parity tend to have an elevated risk of PABC but reduced risk of non-PABC (p for heterogeneity = 0.097). Family history of breast cancer might be a strong predictor particularly for PABC 2 or more years postpartum (odds ratio, 3.28; 95% confidence interval, 1.05-10.3). Compared with non-PABC cases, PABC 2 or more years postpartum cases were more likely to carry BRCA1/2 mutations (P = .03). CONCLUSIONS: Parity may have different roles in the development of PABC versus other premenopausal breast cancer in Nigerian women. Prospective mothers with multiple births and a family history of breast cancer may have an elevated risk of breast cancer during their immediate postpartum period.
PURPOSE: Little is known about risk factors for pregnancy-associated breast cancer (PABC), diagnosed during pregnancy or postpartum. METHODS: We enrolled 1715 premenopausal women from the Nigerian Breast Cancer Study from 1998 to 2011. Based on recency of last pregnancy from diagnosis, breast cancer cases were categorized as (1) PABC diagnosed 2 years or longer postpartum, (2) PABC diagnosed 3 to 5 years postpartum, or (3) non-PABC diagnosed more than 5 years postpartum. Controls were matched to cases on recency of last pregnancy. Multiple logistic regressions were performed comparing cases and controls within each group. RESULTS: Of the 718 cases, 152 (21.2%) had PABC 2 or more years postpartum, and 145 (20.2%) 3 to 5 years postpartum. Although not statistically significant, women with higher parity tend to have an elevated risk of PABC but reduced risk of non-PABC (p for heterogeneity = 0.097). Family history of breast cancer might be a strong predictor particularly for PABC 2 or more years postpartum (odds ratio, 3.28; 95% confidence interval, 1.05-10.3). Compared with non-PABC cases, PABC 2 or more years postpartum cases were more likely to carry BRCA1/2 mutations (P = .03). CONCLUSIONS: Parity may have different roles in the development of PABC versus other premenopausal breast cancer in Nigerian women. Prospective mothers with multiple births and a family history of breast cancer may have an elevated risk of breast cancer during their immediate postpartum period.
Authors: Traci R Lyons; Jenean O'Brien; Virginia F Borges; Matthew W Conklin; Patricia J Keely; Kevin W Eliceiri; Andriy Marusyk; Aik-Choon Tan; Pepper Schedin Journal: Nat Med Date: 2011-08-07 Impact factor: 53.440
Authors: Hatem A Azim; Luigi Santoro; William Russell-Edu; George Pentheroudakis; Nicholas Pavlidis; Fedro A Peccatori Journal: Cancer Treat Rev Date: 2012-07-09 Impact factor: 12.111
Authors: Michael Helewa; Pierre Lévesque; Diane Provencher; Robert H Lea; Vera Rosolowich; Heather M Shapiro Journal: J Obstet Gynaecol Can Date: 2002-02
Authors: D Huo; C A Adebamowo; T O Ogundiran; E E Akang; O Campbell; A Adenipekun; S Cummings; J Fackenthal; F Ademuyiwa; H Ahsan; O I Olopade Journal: Br J Cancer Date: 2008-02-26 Impact factor: 7.640
Authors: Louise A Brinton; Baffour Awuah; Joe Nat Clegg-Lamptey; Beatrice Wiafe-Addai; Daniel Ansong; Kofi M Nyarko; Seth Wiafe; Joel Yarney; Richard Biritwum; Michelle Brotzman; Andrew A Adjei; Ernest Adjei; Francis Aitpillah; Lawrence Edusei; Florence Dedey; Sarah J Nyante; Joseph Oppong; Ernest Osei-Bonsu; Nicholas Titiloye; Verna Vanderpuye; Emma Brew Abaidoo; Bernard Arhin; Isaac Boakye; Margaret Frempong; Naomi Ohene Oti; Victoria Okyne; Jonine D Figueroa Journal: Int J Cancer Date: 2017-03-28 Impact factor: 7.396
Authors: Amanda M Pugh; Courtney M Giannini; Susan M Pinney; Dennis J Hanseman; Elizabeth A Shaughnessy; Jaime D Lewis Journal: Am J Surg Date: 2018-09-20 Impact factor: 2.565
Authors: Stella O Odedina; IkeOluwapo O Ajayi; Adenike Adeniji-Sofoluwe; Imran O Morhason-Bello; Dezheng Huo; Olufunmilayo I Olopade; Oladosu A Ojengbede Journal: BMC Womens Health Date: 2018-09-19 Impact factor: 2.809
Authors: Josephine Nsaful; Verna Vanderpuye; Aba Anoa Scott; Florence Dedey; Samuel A Oppong; Rita Appiah-Danquah; Nelson Damale; Benjamin Fenu; Theodore Wordui; Joel Yarney; Joe Nat Clegg-Lamptey Journal: Ecancermedicalscience Date: 2020-11-10
Authors: Jean Marie Vianney Dusengimana; Vedaste Hategekimana; Ryan Borg; Bethany Hedt-Gauthier; Neil Gupta; Susan Troyan; Lawrence N Shulman; Ignace Nzayisenga; Temidayo Fadelu; Tharcisse Mpunga; Lydia E Pace Journal: BMC Cancer Date: 2018-06-05 Impact factor: 4.430