Literature DB >> 238778

The influence of cholinoceptor activity on the mitotic rate in the crypts of Lieberkühn in rat jejunum.

P J Tutton.   

Abstract

1. The influence of cholinoceptor stimulation and cholinoceptor blockade on the mitotic rate in epithelial cells lining the crypts of Lieberkühn in rat jejunum was studied. 2. Cholinoceptor stimulation, either by injection of carbachol or by inhibition of acetylcholinesterase enzymes resulted in an increase in the mitotic rate. This increase in mitotic rate was blocked by tubocurarine, but not by atropine or hexamethonium. Atropine by itself increased the mitotic rate whereas tubocurarine alone or hexamethonium along decreased the mitotic rate. 3. The influence of atropine on crypt cell proliferation appears to involve an adrenergic mechanism since it is blocked by phentolamine.

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Year:  1975        PMID： 238778     DOI： 10.1111/j.1440-1681.1975.tb03032.x

Source DB:  PubMed          Journal:  Clin Exp Pharmacol Physiol        ISSN： 0305-1870            Impact factor:   2.557


  8 in total

1.  The M1 muscarinic acetylcholine receptor in the crypt stem cell compartment mediates intestinal mucosal growth.

Authors:  Chasen J Greig; Sarah J Armenia; Robert A Cowles
Journal:  Exp Biol Med (Maywood)       Date:  2020-07-01

2.  Analysis of intestinal cell proliferation after guanethidine-induced sympathectomy. I. Stathmokinetic, labelling index, mitotic index, and cellular migration studies.

Authors:  R M Klein; J Torres
Journal:  Cell Tissue Res       Date:  1978-12-28       Impact factor: 5.249

3.  Localization of the effect of acetylcholine in regulating intestinal ion transport.

Authors:  J G Browning; J Hardcastle; P T Hardcastle; J S Redfern
Journal:  J Physiol       Date:  1978-08       Impact factor: 5.182

4.  Isoprenaline protects intestinal stem cells from chemotherapy-induced damage.

Authors:  Huihong Zeng; Huan Li; Mengzhen Yue; Ying Fan; Jiaoqi Cheng; Xincheng Wu; Rui Xu; Wuping Yang; Manjun Li; Jiahui Tang; Hongping Chen; Bohai Kuang; Guangqin Fan; Qingxian Zhu; Lijian Shao
Journal:  Br J Pharmacol       Date:  2020-01-03       Impact factor: 8.739

5.  Intestinal epithelial stem/progenitor cells are controlled by mucosal afferent nerves.

Authors:  Ove Lundgren; Mats Jodal; Madeleine Jansson; Anders T Ryberg; Lennart Svensson
Journal:  PLoS One       Date:  2011-02-09       Impact factor: 3.240

6.  Inhibition by isoproterenol and neostigmine of experimental carcinogenesis in rat colon by azoxymethane.

Authors:  M Tatsuta; H Iishi; H Yamamura; M Baba; H Taniguchi
Journal:  Br J Cancer       Date:  1988-11       Impact factor: 7.640

7.  Hepatocyte Growth Factor and MET Support Mouse Enteric Nervous System Development, the Peristaltic Response, and Intestinal Epithelial Proliferation in Response to Injury.

Authors:  Marina Avetisyan; Hongtao Wang; Ellen Merrick Schill; Saya Bery; John R Grider; John A Hassell; Thaddeus Stappenbeck; Robert O Heuckeroth
Journal:  J Neurosci       Date:  2015-08-19       Impact factor: 6.167

Review 8.  Regulation of the Autonomic Nervous System on Intestine.

Authors:  Hongyi Duan; Xueqin Cai; Yingying Luan; Shuo Yang; Juan Yang; Hui Dong; Huihong Zeng; Lijian Shao
Journal:  Front Physiol       Date:  2021-07-14       Impact factor: 4.566
  8 in total

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