Literature DB >> 32611198

The M1 muscarinic acetylcholine receptor in the crypt stem cell compartment mediates intestinal mucosal growth.

Chasen J Greig1, Sarah J Armenia1, Robert A Cowles1.   

Abstract

IMPACT STATEMENT: Localization of a specific subtype of the muscarinic acetylcholine receptor in the crypt stem cell compartment suggests a critical role in intestinal mucosal homeostasis. Here we demonstrate the localization of the M1 muscarinic acetylcholine receptor to the stem cell compartment and demonstrate increase morphometric and proliferative parameters when this is stimulated in vivo. These data provide novel information about this complex signaling microenvironment and offer potential future therapeutic targets for future study.

Entities:  

Keywords:  Muscarinic acetylcholine receptors; intestinal crypts; intestinal homeostasis; intestinal stem cells; mouse model; mucosal growth

Mesh：

Substances：

Year:  2020        PMID： 32611198      PMCID： PMC7437377          DOI： 10.1177/1535370220938375

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


  23 in total

Review 1.  Neurotransmitters in neuronal reflexes regulating intestinal secretion.

Authors:  H J Cooke
Journal:  Ann N Y Acad Sci       Date:  2000       Impact factor: 5.691

2.  The myenteric plexus regulates cell growth in rat jejunum.

Authors:  N A See; M L Epstein; J L Dahl; P Bass
Journal:  J Auton Nerv Syst       Date:  1990-12

3.  Immunohistochemical localisation of cholinergic muscarinic receptor subtype 1 (M1r) in the guinea pig and human enteric nervous system.

Authors:  A M Harrington; J M Hutson; B R Southwell
Journal:  J Chem Neuroanat       Date:  2007-03-23       Impact factor: 3.052

4.  Neuronal serotonin regulates growth of the intestinal mucosa in mice.

Authors:  Erica R Gross; Michael D Gershon; Kara G Margolis; Zoya V Gertsberg; Zhishan Li; Robert A Cowles
Journal:  Gastroenterology       Date:  2012-05-15       Impact factor: 22.682

5.  Neural stimulation of mitotic activity in the crypts of lieberkühn in rat jejunum.

Authors:  P J Tutton
Journal:  Cell Tissue Kinet       Date:  1975-05

6.  Distribution of muscarinic acetylcholine receptor subtypes in the murine small intestine.

Authors:  Eleanor D Muise; Neeru Gandotra; John J Tackett; Michaela C Bamdad; Robert A Cowles
Journal:  Life Sci       Date:  2016-11-17       Impact factor: 5.037

7.  Muscarinic acetylcholine receptors participate in small intestinal mucosal homeostasis.

Authors:  Chasen J Greig; Robert A Cowles
Journal:  J Pediatr Surg       Date:  2017-03-18       Impact factor: 2.545

8.  Roles of M2 and M4 muscarinic receptors in regulating acetylcholine release from myenteric neurons of mouse ileum.

Authors:  Tadayoshi Takeuchi; Kaori Fujinami; Hiroto Goto; Akikazu Fujita; Makoto M Taketo; Toshiya Manabe; Minoru Matsui; Fumiaki Hata
Journal:  J Neurophysiol       Date:  2004-12-01       Impact factor: 2.714

9.  Intestinal epithelial stem/progenitor cells are controlled by mucosal afferent nerves.

Authors:  Ove Lundgren; Mats Jodal; Madeleine Jansson; Anders T Ryberg; Lennart Svensson
Journal:  PLoS One       Date:  2011-02-09       Impact factor: 3.240

10.  Cholinergic muscarinic receptor activation augments murine intestinal epithelial cell proliferation and tumorigenesis.

Authors:  Zhongsheng Peng; Jonathon Heath; Cinthia Drachenberg; Jean-Pierre Raufman; Guofeng Xie
Journal:  BMC Cancer       Date:  2013-04-24       Impact factor: 4.430
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.