Jianping Jia1, Fen Wang2, Cuibai Wei2, Aihong Zhou2, Xiangfei Jia3, Fang Li4, Muni Tang5, Lan Chu6, Youlong Zhou7, Chunkui Zhou8, Yong Cui9, Qi Wang2, Weishan Wang10, Peng Yin11, Nan Hu11, Xiumei Zuo2, Haiqing Song2, Wei Qin2, Liyong Wu2, Dan Li2, Longfei Jia12, Juexian Song2, Ying Han2, Yi Xing2, Peijie Yang2, Yuemei Li2, Yuchen Qiao2, Yi Tang2, Jihui Lv10, Xiumin Dong2. 1. Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, P. R. China. Electronic address: jjp@ccmu.edu.cn. 2. Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, P. R. China. 3. Department of Computer Science, University of Otago, Dunedin, New Zealand. 4. Department of Neurology, Fu Xing Hospital, Capital Medical University, Beijing, P. R. China. 5. Department of Geriatrics, Guangzhou Brain Hospital, Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong Province, P. R. China. 6. Department of Neurology, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou Province, P. R. China. 7. Department of Neurology, Third Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, P. R. China. 8. Department of Neurology, First Hospital of Jilin University, Changchun, Jinlin Province, P. R. China. 9. Department of Neurology, Fourth Hospital of Jilin University, Changchun, Jinlin Province, P. R. China. 10. Department of Neurology, Beijing Geriatric Hospital, Beijing, P. R. China. 11. National Center for Chronic and Noncommunicable Disease Control and Prevention, Beijing, P. R. China. 12. Department of Neurology, Tongren Hospital, Capital Medical University, Beijing, P. R. China.
Abstract
OBJECTIVE: The Chinese population has been aging rapidly and the country's economy has experienced exponential growth during the past three decades. The goal of this study was to estimate the changes in the prevalence of dementia, Alzheimer's disease (AD), and vascular dementia (VaD) among elderly Chinese individuals and to analyze differences between urban and rural areas. METHODS: For the years 2008 to 2009, we performed a population-based cross-sectional survey with a multistage cluster sampling design. Residents aged 65 years and older were drawn from 30 urban (n = 6096) and 45 rural (n = 4180) communities across China. Participants were assessed with a series of clinical examinations and neuropsychological measures. Dementia, AD, and VaD were diagnosed according to established criteria via standard diagnostic procedures. RESULTS: The prevalence of dementia, AD, and VaD among individuals aged 65 years and older were 5.14% (95% CI, 4.71-5.57), 3.21% (95% CI, 2.87-3.55), and 1.50% (95% CI, 1.26-1.74), respectively. The prevalence of dementia was significantly higher in rural areas than in urban ones (6.05% vs. 4.40%, P < .001). The same regional difference was also seen for AD (4.25% vs. 2.44%, P < .001) but not for VaD (1.28% vs. 1.61%, P = .166). The difference in AD was not evident when the sample was stratified by educational level. Moreover, the risk factors for AD and VaD differed for urban and rural populations. CONCLUSIONS: A notably higher prevalence of dementia and AD was found in rural areas than in urban ones, and education might be an important reason for the urban-rural differences.
OBJECTIVE: The Chinese population has been aging rapidly and the country's economy has experienced exponential growth during the past three decades. The goal of this study was to estimate the changes in the prevalence of dementia, Alzheimer's disease (AD), and vascular dementia (VaD) among elderly Chinese individuals and to analyze differences between urban and rural areas. METHODS: For the years 2008 to 2009, we performed a population-based cross-sectional survey with a multistage cluster sampling design. Residents aged 65 years and older were drawn from 30 urban (n = 6096) and 45 rural (n = 4180) communities across China. Participants were assessed with a series of clinical examinations and neuropsychological measures. Dementia, AD, and VaD were diagnosed according to established criteria via standard diagnostic procedures. RESULTS: The prevalence of dementia, AD, and VaD among individuals aged 65 years and older were 5.14% (95% CI, 4.71-5.57), 3.21% (95% CI, 2.87-3.55), and 1.50% (95% CI, 1.26-1.74), respectively. The prevalence of dementia was significantly higher in rural areas than in urban ones (6.05% vs. 4.40%, P < .001). The same regional difference was also seen for AD (4.25% vs. 2.44%, P < .001) but not for VaD (1.28% vs. 1.61%, P = .166). The difference in AD was not evident when the sample was stratified by educational level. Moreover, the risk factors for AD and VaD differed for urban and rural populations. CONCLUSIONS: A notably higher prevalence of dementia and AD was found in rural areas than in urban ones, and education might be an important reason for the urban-rural differences.
Authors: Karin Fehsel; Tamara Schikowski; Michaela Jänner; Anke Hüls; Mohammed Voussoughi; Thomas Schulte; Andrea Vierkötter; Tom Teichert; Christian Herder; Dorothea Sugiri; Ursula Krämer; Christian Luckhaus Journal: J Neural Transm (Vienna) Date: 2016-09-14 Impact factor: 3.575