Literature DB >> 23868508

The effect of vitamin A supplementation on retinoic acid-related orphan receptor γt (RORγt) and interleukin-17 (IL-17) gene expression in Avonex-treated multiple sclerotic patients.

Niyaz Mohammadzadeh Honarvar1, Mohammad Hossein Harirchian, Fariba Koohdani, Feridoun Siassi, Mina Abdolahi, Sama Bitarafan, Eisa Salehi, Mohammad Ali Sahraian, Mohammad Reza Eshraghian, Ali Akbar Saboor-Yarghi.   

Abstract

The aim of this study was to investigate the role of vitamin A on RORγt and IL-17 gene expression in multiple sclerotic patients. Patients in the vitamin A group received 25,000 IU retinyl palmitate per day, while patients in the placebo group took one capsule of placebo per day for 6 months. Gene expression was measured by real-time PCR at the first and end of the study. The results of this study show that vitamin A downregulates IL-17 and RORγt gene expression. No changes in gene expression occurred in the placebo group.

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Year:  2013        PMID： 23868508     DOI： 10.1007/s12031-013-0058-9

Source DB:  PubMed          Journal:  J Mol Neurosci        ISSN： 0895-8696            Impact factor:   3.444


  29 in total

1.  The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells.

Authors:  Ivaylo I Ivanov; Brent S McKenzie; Liang Zhou; Carlos E Tadokoro; Alice Lepelley; Juan J Lafaille; Daniel J Cua; Dan R Littman
Journal:  Cell       Date:  2006-09-22       Impact factor: 41.582

Review 2.  Th17 cell, the new player of neuroinflammatory process in multiple sclerosis.

Authors:  F Jadidi-Niaragh; A Mirshafiey
Journal:  Scand J Immunol       Date:  2011-07       Impact factor: 3.487

3.  Neutralization of IL-9 ameliorates experimental autoimmune encephalomyelitis by decreasing the effector T cell population.

Authors:  Hongmei Li; Bardia Nourbakhsh; Bogoljub Ciric; Guang-Xian Zhang; Abdolmohamad Rostami
Journal:  J Immunol       Date:  2010-08-30       Impact factor: 5.422

Review 4.  Retinoic acid in the immune system.

Authors:  Karina Pino-Lagos; Micah J Benson; Randolph J Noelle
Journal:  Ann N Y Acad Sci       Date:  2008-11       Impact factor: 5.691

5.  Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway.

Authors:  Kevin M Elias; Arian Laurence; Todd S Davidson; Geoffrey Stephens; Yuka Kanno; Ethan M Shevach; John J O'Shea
Journal:  Blood       Date:  2007-10-19       Impact factor: 22.113

6.  Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis.

Authors:  Verena Brucklacher-Waldert; Klarissa Stuerner; Manuela Kolster; Julia Wolthausen; Eva Tolosa
Journal:  Brain       Date:  2009-12       Impact factor: 13.501

7.  Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid.

Authors:  Daniel Mucida; Yunji Park; Gisen Kim; Olga Turovskaya; Iain Scott; Mitchell Kronenberg; Hilde Cheroutre
Journal:  Science       Date:  2007-06-14       Impact factor: 47.728

Review 8.  Th17 Cells in MS and Experimental Autoimmune Encephalomyelitis.

Authors:  Hh Hofstetter; R Gold; H-P Hartung
Journal:  Int MS J       Date:  2009-04

9.  Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells.

Authors:  Monica Montes; Xin Zhang; Laureline Berthelot; David-Axel Laplaud; Sophie Brouard; Jianping Jin; Sarah Rogan; Diane Armao; Valerie Jewells; Jean-Paul Soulillou; Silva Markovic-Plese
Journal:  Clin Immunol       Date:  2008-11-05       Impact factor: 3.969

Review 10.  Regulation of FoxP3 regulatory T cells and Th17 cells by retinoids.

Authors:  Chang H Kim
Journal:  Clin Dev Immunol       Date:  2008
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  12 in total

Review 1.  Molecular Mechanisms of the Action of Vitamin A in Th17/Treg Axis in Multiple Sclerosis.

Authors:  Mina Abdolahi; Parvaneh Yavari; Niyaz Mohammadzadeh Honarvar; Sama Bitarafan; Maryam Mahmoudi; Ali Akbar Saboor-Yaraghi
Journal:  J Mol Neurosci       Date:  2015-08-30       Impact factor: 3.444

Review 2.  The Molecular Mechanisms of Vitamin A Deficiency in Multiple Sclerosis.

Authors:  Ahmad Reza Dorosty-Motlagh; Niyaz Mohammadzadeh Honarvar; Mohsen Sedighiyan; Mina Abdolahi
Journal:  J Mol Neurosci       Date:  2016-06-29       Impact factor: 3.444

3.  Impact of vitamin A supplementation on RAR gene expression in multiple sclerosis patients.

Authors:  Sama Bitarafan; Mohammad Hossein Harirchian; Mohammad Ali Sahraian; Mohammad Keramatipour; Nahid Beladi Moghadam; Mansoureh Togha; Shahriar Nafissi; Fereydoun Siassi; Mohammad Reza Eshraghian; Niyaz Mohammadzadeh Honarvar; Hasti Ansar; Saeed Talebi; Ali Akbar Saboor-Yarghi
Journal:  J Mol Neurosci       Date:  2013-08-17       Impact factor: 3.444

Review 4.  Molecular Anti-inflammatory Mechanisms of Retinoids and Carotenoids in Alzheimer's Disease: a Review of Current Evidence.

Authors:  Niyaz Mohammadzadeh Honarvar; Ahmad Saedisomeolia; Mina Abdolahi; Amir Shayeganrad; Gholamreza Taheri Sangsari; Babak Hassanzadeh Rad; Gerald Muench
Journal:  J Mol Neurosci       Date:  2016-11-18       Impact factor: 3.444

5.  The Effect of Vitamin A Supplementation on FoxP3 and TGF-β Gene Expression in Avonex-Treated Multiple Sclerosis Patients.

Authors:  Ali Akbar Saboor-Yaraghi; Mohammad Hossein Harirchian; Niyaz Mohammadzadeh Honarvar; Sama Bitarafan; Mina Abdolahi; Feridoun Siassi; Eisa Salehi; Mohammad Ali Sahraian; Mohammad Reza Eshraghian; Tina Roostaei; Fariba Koohdani
Journal:  J Mol Neurosci       Date:  2015-05-19       Impact factor: 3.444

Review 6.  The evidence for a beneficial role of vitamin A in multiple sclerosis.

Authors:  Yara Dadalti Fragoso; Patrick N Stoney; Peter J McCaffery
Journal:  CNS Drugs       Date:  2014-04       Impact factor: 5.749

7.  Retinyl Palmitate Supplementation Modulates T-bet and Interferon Gamma Gene Expression in Multiple Sclerosis Patients.

Authors:  Niyaz Mohammadzadeh Honarvar; Mohammad Hossein Harirchian; Mina Abdolahi; Elahe Abedi; Sama Bitarafan; Fariba Koohdani; Feridoun Siassi; Mohammad Ali Sahraian; Reza Chahardoli; Mahnaz Zareei; Eisa Salehi; Maziyar Geranmehr; Ali Akbar Saboor-Yaraghi
Journal:  J Mol Neurosci       Date:  2016-04-28       Impact factor: 3.444

8.  Treatment of progressive multiple sclerosis with high-dose all-trans retinoic acid - no clear evidence of positive disease modifying effects.

Authors:  Christoph Ruschil; Evelyn Dubois; Maria-Ioanna Stefanou; Markus Christian Kowarik; Ulf Ziemann; Marcus Schittenhelm; Markus Krumbholz; Felix Bischof
Journal:  Neurol Res Pract       Date:  2021-05-10

9.  Dietary interventions for multiple sclerosis-related outcomes.

Authors:  Natalie E Parks; Caitlin S Jackson-Tarlton; Laura Vacchi; Roah Merdad; Bradley C Johnston
Journal:  Cochrane Database Syst Rev       Date:  2020-05-19

10.  Serum retinol levels are associated with brain volume loss in patients with multiple sclerosis.

Authors:  H Yokote; T Kamata; S Toru; N Sanjo; T Yokota
Journal:  Mult Scler J Exp Transl Clin       Date:  2017-09-11
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