| Literature DB >> 27122150 |
Niyaz Mohammadzadeh Honarvar1, Mohammad Hossein Harirchian2, Mina Abdolahi1, Elahe Abedi1, Sama Bitarafan3, Fariba Koohdani1, Feridoun Siassi4, Mohammad Ali Sahraian2, Reza Chahardoli1, Mahnaz Zareei1, Eisa Salehi5, Maziyar Geranmehr1, Ali Akbar Saboor-Yaraghi6,7.
Abstract
Vitamin A derivatives such as retinoic acid may improve the impaired balance of CD4+ T cells in autoimmune and inflammatory diseases. This study is a double-blind randomized trial to evaluate the effect of vitamin A (as form of retinyl palmitate) supplementation on multiple sclerosis (MS) patients. Thirty-nine patients were enrolled and randomly assigned to two groups. Both groups were followed for 6 months. The experimental group received 25,000 IU of retinyl palmitate daily, while the control group received a placebo. Before and after the study, the expression of interferon gamma (IFN-γ) and T-bet genes was evaluated in peripheral blood mononuclear cells of patients by RT-PCR. The results showed that after 6 months of supplementation, expression of IFN-γ and T-bet was significantly decreased. These data suggest that retinyl palmitate supplementation can modulate the impaired balance of Th1 and Th2 cells and vitamin A products that may be involved in the therapeutic mechanism of vitamin A in MS patients. This study provides information regarding the decreased gene expression of IFN-γ and T-bet in MS by retinyl palmitate supplementation.Entities:
Keywords: IFN-γ; Multiple sclerosis; Retinyl palmitate; T-bet
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Year: 2016 PMID： 27122150 DOI： 10.1007/s12031-016-0747-2
Source DB: PubMed Journal: J Mol Neurosci ISSN： 0895-8696 Impact factor: 3.444