Jessica Peter1, Lukas Scheef2, Ahmed Abdulkadir3, Henning Boecker4, Michael Heneka5, Michael Wagner6, Alexander Koppara7, Stefan Klöppel8, Frank Jessen6. 1. Freiburg Brain Imaging, University Medical Center Freiburg, Freiburg, Germany; Department of Neurology, University Medical Center Freiburg, Freiburg, Germany; Department of Psychology, Laboratory for Biological and Personality Psychology, University of Freiburg, Freiburg, Germany. Electronic address: jessica.peter@uniklinik-freiburg.de. 2. Department of Radiology, University Hospital Bonn, Bonn, Germany. 3. Freiburg Brain Imaging, University Medical Center Freiburg, Freiburg, Germany; Group of Pattern Recognition and Image Processing, Department of Computer Science, University of Freiburg, Freiburg, Germany. 4. Department of Radiology, University Hospital Bonn, Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE) Bonn, Bonn, Germany. 5. German Center for Neurodegenerative Diseases (DZNE) Bonn, Bonn, Germany; Department of Neurology, University of Bonn, Bonn, Germany; Clinical Neuroscience Unit, Department of Neurology, University of Bonn, Bonn, Germany. 6. Department of Psychiatry and Psychotherapy, Rheinische-Friedrich-Wilhelms University Bonn, Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE) Bonn, Bonn, Germany. 7. Department of Psychiatry and Psychotherapy, Rheinische-Friedrich-Wilhelms University Bonn, Bonn, Germany. 8. Freiburg Brain Imaging, University Medical Center Freiburg, Freiburg, Germany; Department of Neurology, University Medical Center Freiburg, Freiburg, Germany; Department of Psychiatry and Psychotherapy, Section of Gerontopsychiatry and Neuropsychology, University Medical Center Freiburg, Freiburg, Germany.
Abstract
BACKGROUND: Individuals with subjective memory impairment (SMI) report worsening of memory without impairment in cognitive tests. Despite normal cognitive performance, they may be at higher risk of cognitive decline compared with individuals without SMI. METHODS: We used a discriminative function (a support vector machine) trained on an independent data set of 226 healthy control subjects and 191 patients with probable Alzheimer's disease (AD) dementia to characterize the baseline gray matter patterns of 24 individuals with SMI and 53 control subjects. We tested for associations of these gray matter patterns with SMI presence, cognitive performance at baseline, and cognitive decline at follow-up. RESULTS: Individuals with SMI showed greater similarity to an AD gray matter pattern compared with control subjects without SMI. In addition, episodic memory decline was associated with an AD gray matter pattern in the SMI group. CONCLUSIONS: Our results indicate a link between the gray matter atrophy pattern of patients with AD and the presence of SMI. Furthermore, multivariate pattern recognition approaches seem to be a sensitive method for identifying subtle brain changes that correspond to future memory decline in SMI.
BACKGROUND: Individuals with subjective memory impairment (SMI) report worsening of memory without impairment in cognitive tests. Despite normal cognitive performance, they may be at higher risk of cognitive decline compared with individuals without SMI. METHODS: We used a discriminative function (a support vector machine) trained on an independent data set of 226 healthy control subjects and 191 patients with probable Alzheimer's disease (AD) dementia to characterize the baseline gray matter patterns of 24 individuals with SMI and 53 control subjects. We tested for associations of these gray matter patterns with SMI presence, cognitive performance at baseline, and cognitive decline at follow-up. RESULTS: Individuals with SMI showed greater similarity to an AD gray matter pattern compared with control subjects without SMI. In addition, episodic memory decline was associated with an AD gray matter pattern in the SMI group. CONCLUSIONS: Our results indicate a link between the gray matter atrophy pattern of patients with AD and the presence of SMI. Furthermore, multivariate pattern recognition approaches seem to be a sensitive method for identifying subtle brain changes that correspond to future memory decline in SMI.
Authors: Richard J Kryscio; Erin L Abner; Gregory E Cooper; David W Fardo; Gregory A Jicha; Peter T Nelson; Charles D Smith; Linda J Van Eldik; Lijie Wan; Frederick A Schmitt Journal: Neurology Date: 2014-09-24 Impact factor: 9.910
Authors: Nancy J Donovan; Rebecca E Amariglio; Amy S Zoller; Rebecca K Rudel; Teresa Gomez-Isla; Deborah Blacker; Bradley T Hyman; Joseph J Locascio; Keith A Johnson; Reisa A Sperling; Gad A Marshall; Dorene M Rentz Journal: Am J Geriatr Psychiatry Date: 2014-02-26 Impact factor: 4.105
Authors: Frank Jessen; Rebecca E Amariglio; Martin van Boxtel; Monique Breteler; Mathieu Ceccaldi; Gaël Chételat; Bruno Dubois; Carole Dufouil; Kathryn A Ellis; Wiesje M van der Flier; Lidia Glodzik; Argonde C van Harten; Mony J de Leon; Pauline McHugh; Michelle M Mielke; Jose Luis Molinuevo; Lisa Mosconi; Ricardo S Osorio; Audrey Perrotin; Ronald C Petersen; Laura A Rabin; Lorena Rami; Barry Reisberg; Dorene M Rentz; Perminder S Sachdev; Vincent de la Sayette; Andrew J Saykin; Philip Scheltens; Melanie B Shulman; Melissa J Slavin; Reisa A Sperling; Robert Stewart; Olga Uspenskaya; Bruno Vellas; Pieter Jelle Visser; Michael Wagner Journal: Alzheimers Dement Date: 2014-05-03 Impact factor: 21.566
Authors: Colette M Smart; Justin E Karr; Corson N Areshenkoff; Laura A Rabin; Carol Hudon; Nicola Gates; Jordan I Ali; Eider M Arenaza-Urquijo; Rachel F Buckley; Gael Chetelat; Harald Hampel; Frank Jessen; Natalie L Marchant; Sietske A M Sikkes; Andrea Tales; Wiesje M van der Flier; Linda Wesselman Journal: Neuropsychol Rev Date: 2017-03-07 Impact factor: 7.444
Authors: B Vellas; I Carrie; S Gillette-Guyonnet; J Touchon; T Dantoine; J F Dartigues; M N Cuffi; S Bordes; Y Gasnier; P Robert; L Bories; O Rouaud; F Desclaux; K Sudres; M Bonnefoy; A Pesce; C Dufouil; S Lehericy; M Chupin; J F Mangin; P Payoux; D Adel; P Legrand; D Catheline; C Kanony; M Zaim; L Molinier; N Costa; J Delrieu; T Voisin; C Faisant; F Lala; F Nourhashémi; Y Rolland; G Abellan Van Kan; C Dupuy; C Cantet; P Cestac; S Belleville; S Willis; M Cesari; M W Weiner; M E Soto; P J Ousset; S Andrieu Journal: J Prev Alzheimers Dis Date: 2014-06