BACKGROUND: Vitamin D regulates the renin-angiotensin system, suppresses proliferation of vascular smooth muscle and improves endothelial cell dependent vasodilatation. These mechanisms may play a role on pathogenesis of arterial and left ventricular stiffness. OBJECTIVES: We aimed to investigate the association between serum 25-hydroxyvitamin D with arterial and left ventricular stiffness in healthy subjects. METHODS: We studied 125 healthy subjects without known cardiovascular risk factors or overt heart disease (mean age: 60.2 ± 11.9 years). Serum 25-hydroxyvitamin D was measured using a direct competitive chemiluminescent immunoassay. The subjects were divided into two groups according to the serum vitamin D level; vitamin D sufficient (≥ 20 ng/ml, n = 56) and vitamin D deficient (<20 ng/ml, n = 69). Indexes of LV stiffness such as E/A and E/E' were measured. Pulse wave velocity (PWV), which reflects arterial stiffness, was calculated using the single-point method via the Mobil-O-Graph(®) ARC solver algorithm. RESULTS: Systolic blood pressure, level of serum calcium, PWV and E/E' values were higher and E/A values were lower in vitamin D deficient group compared with vitamin D sufficient group. Multiple linear regression analysis showed that vitamin D level was independently associated with E/E' (β = -0.364, p<0.001), serum calcium (r = -0.136, p = 0.014), PWV (β = -0.203, p = 0.003), E/A (β = 0.209, p = 0.001) and systolic blood pressure (β = -0.293, p<0.001). CONCLUSION: 25-Hydroxyvitamin D levels are associated with increased ventricular and arterial stiffness as well as systolic blood pressure in healthy subjects.
BACKGROUND:Vitamin D regulates the renin-angiotensin system, suppresses proliferation of vascular smooth muscle and improves endothelial cell dependent vasodilatation. These mechanisms may play a role on pathogenesis of arterial and left ventricular stiffness. OBJECTIVES: We aimed to investigate the association between serum 25-hydroxyvitamin D with arterial and left ventricular stiffness in healthy subjects. METHODS: We studied 125 healthy subjects without known cardiovascular risk factors or overt heart disease (mean age: 60.2 ± 11.9 years). Serum 25-hydroxyvitamin D was measured using a direct competitive chemiluminescent immunoassay. The subjects were divided into two groups according to the serum vitamin D level; vitamin D sufficient (≥ 20 ng/ml, n = 56) and vitamin D deficient (<20 ng/ml, n = 69). Indexes of LV stiffness such as E/A and E/E' were measured. Pulse wave velocity (PWV), which reflects arterial stiffness, was calculated using the single-point method via the Mobil-O-Graph(®) ARC solver algorithm. RESULTS: Systolic blood pressure, level of serum calcium, PWV and E/E' values were higher and E/A values were lower in vitamin D deficient group compared with vitamin D sufficient group. Multiple linear regression analysis showed that vitamin D level was independently associated with E/E' (β = -0.364, p<0.001), serum calcium (r = -0.136, p = 0.014), PWV (β = -0.203, p = 0.003), E/A (β = 0.209, p = 0.001) and systolic blood pressure (β = -0.293, p<0.001). CONCLUSION:25-Hydroxyvitamin D levels are associated with increased ventricular and arterial stiffness as well as systolic blood pressure in healthy subjects.
Authors: Priscila Portugal Dos Santos; Bruna Paola Murino Rafacho; Andréa de Freitas Gonçalves; Rodrigo Gibin Jaldin; Thiago Bruder do Nascimento; Marcondes Alves Barbosa Silva; Stêfany Bruno Assis Cau; Meliza Goi Roscani; Paula Schimdt Azevedo; Marcos Ferreira Minicucci; Rita de Cássia Tostes; Leonardo Antonio Memede Zornoff; Sergio Alberto Rupp de Paiva Journal: PLoS One Date: 2014-06-12 Impact factor: 3.240
Authors: Nonanzit Pérez-Hernández; Gad Aptilon-Duque; María Cristina Nostroza-Hernández; Gilberto Vargas-Alarcón; José Manuel Rodríguez-Pérez; Ruben Blachman-Braun Journal: Korean J Intern Med Date: 2016-04-27 Impact factor: 2.884