BACKGROUND: To date evidence of the relationship between cognition and Aβ amyloid during the early stages of Alzheimer's Disease (AD) has been inconsistent. This study aimed to describe the nature and magnitude of the relationship between Aβ amyloid and cognitive performance of individuals without dementia. METHODS: Composite cognitive measures were developed from the Australian Imaging Biomarkers and Lifestyle study neuropsychological test battery using data from 768 healthy older adults and 133 adults with mild cognitive impairment (MCI). A subgroup of this sample (174 healthy, 53 MCI) underwent neuroimaging for Aβ amyloid. RESULTS: Within the MCI group individuals with high Aβ amyloid showed selective impairment for memory compared with those with low Aβ amyloid; however, this difference was not evident in the healthy group. CONCLUSIONS: The current findings provide further evidence of the relationship between Aβ amyloid and cognition, with memory impairment being the primary symptom of the underlying disease during the prodromal phases of AD.
BACKGROUND: To date evidence of the relationship between cognition and Aβ amyloid during the early stages of Alzheimer's Disease (AD) has been inconsistent. This study aimed to describe the nature and magnitude of the relationship between Aβ amyloid and cognitive performance of individuals without dementia. METHODS: Composite cognitive measures were developed from the Australian Imaging Biomarkers and Lifestyle study neuropsychological test battery using data from 768 healthy older adults and 133 adults with mild cognitive impairment (MCI). A subgroup of this sample (174 healthy, 53 MCI) underwent neuroimaging for Aβ amyloid. RESULTS: Within the MCI group individuals with high Aβ amyloid showed selective impairment for memory compared with those with low Aβ amyloid; however, this difference was not evident in the healthy group. CONCLUSIONS: The current findings provide further evidence of the relationship between Aβ amyloid and cognition, with memory impairment being the primary symptom of the underlying disease during the prodromal phases of AD.
Authors: Adam P Mecca; Nicole M Barcelos; Shuo Wang; Anna Brück; Nabeel Nabulsi; Beata Planeta-Wilson; Jennifer Nadelmann; Amanda L Benincasa; Jim Ropchan; Yiyun Huang; Joel Gelernter; Peter H Van Ness; Richard E Carson; Christopher H van Dyck Journal: Neurobiol Aging Date: 2017-10-06 Impact factor: 4.673
Authors: S L Gardener; S R Rainey-Smith; M B Barnes; H R Sohrabi; M Weinborn; Y Y Lim; K Harrington; K Taddei; Y Gu; A Rembach; C Szoeke; K A Ellis; C L Masters; S L Macaulay; C C Rowe; D Ames; J B Keogh; N Scarmeas; R N Martins Journal: Mol Psychiatry Date: 2014-07-29 Impact factor: 15.992
Authors: Piers Johnson; Luke Vandewater; William Wilson; Paul Maruff; Greg Savage; Petra Graham; Lance S Macaulay; Kathryn A Ellis; Cassandra Szoeke; Ralph N Martins; Christopher C Rowe; Colin L Masters; David Ames; Ping Zhang Journal: BMC Bioinformatics Date: 2014-12-08 Impact factor: 3.169
Authors: Rosita Shishegar; Timothy Cox; David Rolls; Pierrick Bourgeat; Vincent Doré; Fiona Lamb; Joanne Robertson; Simon M Laws; Tenielle Porter; Jurgen Fripp; Duygu Tosun; Paul Maruff; Greg Savage; Christopher C Rowe; Colin L Masters; Michael W Weiner; Victor L Villemagne; Samantha C Burnham Journal: Sci Rep Date: 2021-12-10 Impact factor: 4.379
Authors: Christopher Fowler; Stephanie R Rainey-Smith; Sabine Bird; Julia Bomke; Pierrick Bourgeat; Belinda M Brown; Samantha C Burnham; Ashley I Bush; Carolyn Chadunow; Steven Collins; James Doecke; Vincent Doré; Kathryn A Ellis; Lis Evered; Amir Fazlollahi; Jurgen Fripp; Samantha L Gardener; Simon Gibson; Robert Grenfell; Elise Harrison; Richard Head; Liang Jin; Adrian Kamer; Fiona Lamb; Nicola T Lautenschlager; Simon M Laws; Qiao-Xin Li; Lucy Lim; Yen Ying Lim; Andrea Louey; S Lance Macaulay; Lucy Mackintosh; Ralph N Martins; Paul Maruff; Colin L Masters; Simon McBride; Lidija Milicic; Madeline Peretti; Kelly Pertile; Tenielle Porter; Morgan Radler; Alan Rembach; Joanne Robertson; Mark Rodrigues; Christopher C Rowe; Rebecca Rumble; Olivier Salvado; Greg Savage; Brendan Silbert; Magdalene Soh; Hamid R Sohrabi; Kevin Taddei; Tania Taddei; Christine Thai; Brett Trounson; Regan Tyrrell; Michael Vacher; Shiji Varghese; Victor L Villemagne; Michael Weinborn; Michael Woodward; Ying Xia; David Ames Journal: J Alzheimers Dis Rep Date: 2021-06-03
Authors: Y Y Lim; V L Villemagne; S M Laws; R H Pietrzak; P J Snyder; D Ames; K A Ellis; K Harrington; A Rembach; R N Martins; C C Rowe; C L Masters; P Maruff Journal: Mol Psychiatry Date: 2014-10-07 Impact factor: 15.992
Authors: Karra D Harrington; Yen Ying Lim; David Ames; Jason Hassenstab; Simon M Laws; Ralph N Martins; Stephanie Rainey-Smith; Joanne Robertson; Christopher C Rowe; Olivier Salvado; Vincent Doré; Victor L Villemagne; Peter J Snyder; Colin L Masters; Paul Maruff Journal: Alzheimers Dement (Amst) Date: 2017-06-09