Literature DB >> 2386546

Cyclosporine A inhibits mitochondrial pyridine nucleotide hydrolysis and calcium release.

C Richter1, M Theus, J Schlegel.   

Abstract

Mitochondria participate in the maintenance of cellular Ca2+ homeostasis. Here we show that the immunosuppressive drug cyclosporine A at low concentrations inhibits release but not uptake of Ca2+ by mitochondria. Prevention of Ca2+ release is due to inhibition of intramitochondrial enzymatic hydrolysis of NAD to ADP-ribose and nicotinamide. These findings suggest a mechanism by which cyclosporine A interferes with cellular Ca2+ homeostasis, and may be related to the immunosuppressive and cytotoxic properties of the drug.

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Year:  1990        PMID： 2386546     DOI： 10.1016/0006-2952(90)90315-c

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  7 in total

Review 1.  The cyclosporins.

Authors:  Z Rehácek
Journal:  Folia Microbiol (Praha)       Date:  1995       Impact factor: 2.099

Review 2.  Permeability transition pore of the inner mitochondrial membrane can operate in two open states with different selectivities.

Authors:  S A Novgorodov; T I Gudz
Journal:  J Bioenerg Biomembr       Date:  1996-04       Impact factor: 2.945

3.  Effects of nimesulide and its reduced metabolite on mitochondria.

Authors:  F E Mingatto; A C dos Santos; T Rodrigues; A A Pigoso; S A Uyemura; C Curti
Journal:  Br J Pharmacol       Date:  2000-11       Impact factor: 8.739

4.  Is the beneficial effect of calcium channel blockers against cyclosporine A toxicity related to a restoration of ATP synthesis?

Authors:  M D Salducci; A M Chauvet-Monges; B M Dussol; Y F Berland; A D Crevat
Journal:  Pharm Res       Date:  1995-04       Impact factor: 4.200

5.  'Pore' formation is not required for the hydroperoxide-induced Ca2+ release from rat liver mitochondria.

Authors:  J Schlegel; M Schweizer; C Richter
Journal:  Biochem J       Date:  1992-07-01       Impact factor: 3.857

6.  DNA damage induced by tumour necrosis factor-alpha in L929 cells is mediated by mitochondrial oxygen radical formation.

Authors:  Y Shoji; Y Uedono; H Ishikura; N Takeyama; T Tanaka
Journal:  Immunology       Date:  1995-04       Impact factor: 7.397

7.  Cytoprotective and antioxidant effects of boldine on tert-butyl hydroperoxide-induced damage to isolated hepatocytes.

Authors:  R Bannach; A Valenzuela; B K Cassels; L J Nunez-Vergara; H Speisky
Journal:  Cell Biol Toxicol       Date:  1996-04       Impact factor: 6.691
  7 in total

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