Literature DB >> 23863720

Coordinated regulation of adipose tissue macrophages by cellular and nutritional signals.

Daniel Har1, Michelle Carey, Meredith Hawkins.   

Abstract

The current epidemic of obesity is fueling a global rise in non-communicable diseases, including type 2 diabetes mellitus, atherothrombotic disease, and cancer. Obesity is associated with systemic inflammation, with various fat-derived inflammatory factors being implicated in the pathophysiology of insulin resistance. The infiltration of various types of inflammatory cells into adipose tissue seems to be an important mechanism whereby nutrient excess contributes to systemic insulin resistance. In particular, adipose tissue macrophages are abundant in obese adipose tissue, and may be the source of the majority of fat-derived circulating inflammatory factors. This review examines recent studies exploring mechanisms whereby cellular and nutritional signals mediate macrophage recruitment to adipose tissue and their pro-inflammatory activation.

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Mesh：

Year:  2013        PMID： 23863720      PMCID： PMC3755875          DOI： 10.2310/JIM.0b013e31829ceb39

Source DB:  PubMed          Journal:  J Investig Med        ISSN： 1081-5589            Impact factor:   2.895


  49 in total

Review 1.  The chemokine system in diverse forms of macrophage activation and polarization.

Authors:  Alberto Mantovani; Antonio Sica; Silvano Sozzani; Paola Allavena; Annunciata Vecchi; Massimo Locati
Journal:  Trends Immunol       Date:  2004-12       Impact factor: 16.687

2.  Obesity induces a phenotypic switch in adipose tissue macrophage polarization.

Authors:  Carey N Lumeng; Jennifer L Bodzin; Alan R Saltiel
Journal:  J Clin Invest       Date:  2007-01       Impact factor: 14.808

3.  CCR2 modulates inflammatory and metabolic effects of high-fat feeding.

Authors:  Stuart P Weisberg; Deborah Hunter; Reid Huber; Jacob Lemieux; Sarah Slaymaker; Kris Vaddi; Israel Charo; Rudolph L Leibel; Anthony W Ferrante
Journal:  J Clin Invest       Date:  2005-12-08       Impact factor: 14.808

Review 4.  Adipose tissue: from lipid storage compartment to endocrine organ.

Authors:  Philipp E Scherer
Journal:  Diabetes       Date:  2006-06       Impact factor: 9.461

5.  TLR4 links innate immunity and fatty acid-induced insulin resistance.

Authors:  Hang Shi; Maia V Kokoeva; Karen Inouye; Iphigenia Tzameli; Huali Yin; Jeffrey S Flier
Journal:  J Clin Invest       Date:  2006-10-19       Impact factor: 14.808

Review 6.  Polyunsaturated fatty acids and inflammation.

Authors:  P C Calder
Journal:  Biochem Soc Trans       Date:  2005-04       Impact factor: 5.407

7.  Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences.

Authors:  Robert D Stout; Chuancang Jiang; Bharati Matta; Illya Tietzel; Stephanie K Watkins; Jill Suttles
Journal:  J Immunol       Date:  2005-07-01       Impact factor: 5.422

Review 8.  Mechanisms linking obesity to insulin resistance and type 2 diabetes.

Authors:  Steven E Kahn; Rebecca L Hull; Kristina M Utzschneider
Journal:  Nature       Date:  2006-12-14       Impact factor: 49.962

9.  Obesity is associated with macrophage accumulation in adipose tissue.

Authors:  Stuart P Weisberg; Daniel McCann; Manisha Desai; Michael Rosenbaum; Rudolph L Leibel; Anthony W Ferrante
Journal:  J Clin Invest       Date:  2003-12       Impact factor: 14.808

10.  Increased plasma levels of plasminogen activator inhibitor-1 and soluble vascular cell adhesion molecule after triacylglycerol infusion in man.

Authors:  Michael Krebs; Margarethe Geiger; Kaija Polak; Anja Vales; Leopold Schmetterer; Oswald F Wagner; Werner Waldhäusl; Bernd R Binder; Michael Roden
Journal:  Thromb Haemost       Date:  2003-09       Impact factor: 5.249
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  3 in total

Review 1.  Microenvironment of Immune Cells Within the Visceral Adipose Tissue Sensu Lato vs. Epicardial Adipose Tissue: What Do We Know?

Authors:  Martin Klein; Ivan Varga
Journal:  Inflammation       Date:  2018-08       Impact factor: 4.092

2.  MAFB as a novel regulator of human adipose tissue inflammation.

Authors:  Annie M L Pettersson; Juan R Acosta; Christel Björk; Johan Krätzel; Britta Stenson; Lennart Blomqvist; Nathalie Viguerie; Dominique Langin; Peter Arner; Jurga Laurencikiene
Journal:  Diabetologia       Date:  2015-06-27       Impact factor: 10.122

3.  Beyond erythropoiesis: emerging metabolic roles of erythropoietin.

Authors:  Minna Woo; Meredith Hawkins
Journal:  Diabetes       Date:  2014-07       Impact factor: 9.461
  3 in total

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