Literature DB >> 23863269

Nucleic acid-programmed assemblies: translating instruction into function in chemical biology.

Nicolas Winssinger1.   

Abstract

The predictability of nucleic acid hybridization offers an attractive platform to program the assembly of tagged ligands or reactants. Hybridization can be used to display multiple ligands in order to gain affinity and/or selectivity through the cooperative interaction of each ligand. Additionally, hybridization of tagged reagents increases their effective concentration and accelerates reactions. In both cases, an oligonucleotide directs an assembly to yield a functional output in the form of enhanced binding, inhibition, or reaction; for example, a reaction can be used to unmask a fluorophore or a bioactive molecule. This review provides an account of our research in this area as well as future directions.

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Year:  2013        PMID： 23863269     DOI： 10.2533/chimia.2013.340

Source DB:  PubMed          Journal:  Chimia (Aarau)        ISSN： 0009-4293            Impact factor:   1.509


  7 in total

1.  PNA-Based Multivalent Scaffolds Activate the Dopamine D2 Receptor.

Authors:  Andrew V Dix; Jennie L Conroy; Kara M George Rosenker; David R Sibley; Daniel H Appella
Journal:  ACS Med Chem Lett       Date:  2015-03-13       Impact factor: 4.345

2.  Comparative evaluation of DNA-encoded chemical selections performed using DNA in single-stranded or double-stranded format.

Authors:  Gabriele Bassi; Nicholas Favalli; Sebastian Oehler; Adriano Martinelli; Marco Catalano; Jörg Scheuermann; Dario Neri
Journal:  Biochem Biophys Res Commun       Date:  2020-05-05       Impact factor: 3.575

3.  Synthesis of DNA-coupled isoquinolones and pyrrolidines by solid phase ytterbium- and silver-mediated imine chemistry.

Authors:  Marco Potowski; Verena B K Kunig; Florian Losch; Andreas Brunschweiger
Journal:  Medchemcomm       Date:  2019-02-26       Impact factor: 3.597

4.  Multivalent LKγ-PNA oligomers bind to a human telomere DNA G-rich sequence to form quadruplexes.

Authors:  Pankaj Gupta; Elizabeth E Rastede; Daniel H Appella
Journal:  Bioorg Med Chem Lett       Date:  2015-07-29       Impact factor: 2.823

5.  A DNA-Encoded Library of Chemical Compounds Based on Common Scaffolding Structures Reveals the Impact of Ligand Geometry on Protein Recognition.

Authors:  Nicholas Favalli; Stefan Biendl; Marco Hartmann; Jacopo Piazzi; Filippo Sladojevich; Susanne Gräslund; Peter J Brown; Katja Näreoja; Herwig Schüler; Jörg Scheuermann; Raphael Franzini; Dario Neri
Journal:  ChemMedChem       Date:  2018-06-01       Impact factor: 3.466

6.  Acid- and Au(i)-mediated synthesis of hexathymidine-DNA-heterocycle chimeras, an efficient entry to DNA-encoded libraries inspired by drug structures.

Authors:  Mateja Klika Škopić; Hazem Salamon; Olivia Bugain; Kathrin Jung; Anne Gohla; Lara J Doetsch; Denise Dos Santos; Avinash Bhat; Bernd Wagner; Andreas Brunschweiger
Journal:  Chem Sci       Date:  2017-02-28       Impact factor: 9.825

7.  Targeted Delivery of Cytotoxic Drugs: Challenges, Opportunities and New Developments.

Authors:  Samuele Cazzamalli; Alberto Dal Corso; Dario Neri
Journal:  Chimia (Aarau)       Date:  2017-10-25       Impact factor: 1.509
  7 in total

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