OBJECTIVE: The relationship between seizures and interictal spikes remains undetermined. We analyzed intracranial EEG (icEEG) recordings to examine the relationship between the seizure onset area and interictal spikes. METHODS: 80 unselected patients were placed into 5 temporal, 4 extratemporal, and one unlocalized groups based on the location of the seizure onset area. We studied 4-h icEEG epochs, removed from seizures, from day-time and night-time during both on- and off-medication periods. Spikes were detected automatically from electrode contacts sampling the hemisphere ipsilateral to the seizure onset area. RESULTS: There was a widespread occurrence of spikes over the hemisphere ipsilateral to the seizure onset area. The spatial distributions of spike rates for the different patient groups were different (p<0.0001, chi-square test). The area with the highest spike rate coincided with the seizure onset area only in half of the patients. CONCLUSION: The spatial distribution of spike rates is strongly associated with the location of the seizure onset area, suggesting the presence of a distributed spike generation network, which is related to the seizure onset area. SIGNIFICANCE: The spatial distribution of spike rates, but not the area with the highest spike rate, may hold value for the localization of the seizure onset area.
OBJECTIVE: The relationship between seizures and interictal spikes remains undetermined. We analyzed intracranial EEG (icEEG) recordings to examine the relationship between the seizure onset area and interictal spikes. METHODS: 80 unselected patients were placed into 5 temporal, 4 extratemporal, and one unlocalized groups based on the location of the seizure onset area. We studied 4-h icEEG epochs, removed from seizures, from day-time and night-time during both on- and off-medication periods. Spikes were detected automatically from electrode contacts sampling the hemisphere ipsilateral to the seizure onset area. RESULTS: There was a widespread occurrence of spikes over the hemisphere ipsilateral to the seizure onset area. The spatial distributions of spike rates for the different patient groups were different (p<0.0001, chi-square test). The area with the highest spike rate coincided with the seizure onset area only in half of the patients. CONCLUSION: The spatial distribution of spike rates is strongly associated with the location of the seizure onset area, suggesting the presence of a distributed spike generation network, which is related to the seizure onset area. SIGNIFICANCE: The spatial distribution of spike rates, but not the area with the highest spike rate, may hold value for the localization of the seizure onset area.
Authors: Joshua M Diamond; Julio I Chapeton; William H Theodore; Sara K Inati; Kareem A Zaghloul Journal: Clin Neurophysiol Date: 2019-07-02 Impact factor: 3.708
Authors: Krishnakant V Saboo; Irena Balzekas; Vaclav Kremen; Yogatheesan Varatharajah; Michal Kucewicz; Ravishankar K Iyer; Gregory A Worrell Journal: Epilepsia Date: 2021-09-18 Impact factor: 5.864
Authors: Robert J Quon; Edward J Camp; Stephen Meisenhelter; Yinchen Song; Sarah A Steimel; Markus E Testorf; Angeline S Andrew; Robert E Gross; Bradley C Lega; Michael R Sperling; Michael J Kahana; Barbara C Jobst Journal: Epilepsia Date: 2021-09-05 Impact factor: 5.864
Authors: Robert J Quon; Stephen Meisenhelter; Richard H Adamovich-Zeitlin; Yinchen Song; Sarah A Steimel; Edward J Camp; Markus E Testorf; Todd A MacKenzie; Robert E Gross; Bradley C Lega; Michael R Sperling; Michael J Kahana; Barbara C Jobst Journal: Epilepsia Date: 2020-12-17 Impact factor: 5.864
Authors: Radek Janca; Pavel Krsek; Petr Jezdik; Roman Cmejla; Martin Tomasek; Vladimir Komarek; Petr Marusic; Premysl Jiruska Journal: Front Neurol Date: 2018-03-23 Impact factor: 4.003
Authors: Robert J Quon; Michael A Casey; Edward J Camp; Stephen Meisenhelter; Sarah A Steimel; Yinchen Song; Markus E Testorf; Grace A Leslie; Krzysztof A Bujarski; Alan B Ettinger; Barbara C Jobst Journal: Sci Rep Date: 2021-09-16 Impact factor: 4.379