Literature DB >> 23855475

The pig as a valuable model for testing the effect of resveratrol to prevent cardiovascular disease.

Nassrene Y Elmadhun1, Ashraf A Sabe, Michael P Robich, Louis M Chu, Antonio D Lassaletta, Frank W Sellke.   

Abstract

Resveratrol is a naturally occurring polyphenol found in the skin of red grapes, peanuts, and red wine that has been shown to modify many cardiovascular risk factors. Small animal models have been extensively used to investigate cardiovascular disease, but the results often fail to translate in clinical trials. Disease-specific pig models are emerging as clinically useful tools that may offer insight into cardiovascular disease and the effect of drugs such as resveratrol on cardiovascular health. In this paper, we discuss the advantage of using clinically relevant pig models of diabetes, hypercholesterolemia, and myocardial ischemia to investigate the role of resveratrol in cardiovascular disease prevention.
© 2013 New York Academy of Sciences.

Entities:  

Keywords:  cardiovascular disease; metabolic syndrome; myocardial ischemia; pig model; resveratrol

Mesh：

Substances：

Year:  2013        PMID： 23855475     DOI： 10.1111/nyas.12216

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  11 in total

Review 1.  Effect of hyperglycaemia and diabetes on acute myocardial ischaemia-reperfusion injury and cardioprotection by ischaemic conditioning protocols.

Authors:  Claudia Penna; Ioanna Andreadou; Manuela Aragno; Christophe Beauloye; Luc Bertrand; Antigone Lazou; Ines Falcão-Pires; Robert Bell; Coert J Zuurbier; Pasquale Pagliaro; Derek J Hausenloy
Journal:  Br J Pharmacol       Date:  2020-03-09       Impact factor: 8.739

2.  Calpain inhibition decreases myocardial apoptosis in a swine model of chronic myocardial ischemia.

Authors:  Brittany A Potz; Ashraf A Sabe; Nassrene Y Elmadhun; Jun Feng; Yuhong Liu; Hunter Mitchell; Peter Quesenberry; M Ruhul Abid; Frank W Sellke
Journal:  Surgery       Date:  2015-05-16       Impact factor: 3.982

3.  Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering.

Authors:  Jiesi Luo; Lingfeng Qin; Mehmet H Kural; Jonas Schwan; Xia Li; Oscar Bartulos; Xiao-Qiang Cong; Yongming Ren; Liqiong Gui; Guangxin Li; Matthew W Ellis; Peining Li; Darrell N Kotton; Alan Dardik; Jordan S Pober; George Tellides; Marsha Rolle; Stuart Campbell; Robert J Hawley; David H Sachs; Laura E Niklason; Yibing Qyang
Journal:  Biomaterials       Date:  2017-09-19       Impact factor: 12.479

4.  Calpain inhibition modulates glycogen synthase kinase 3β pathways in ischemic myocardium: A proteomic and mechanistic analysis.

Authors:  Brittany A Potz; Ashraf A Sabe; Nassrene Y Elmadhun; Richard T Clements; M Ruhul Abid; Neel R Sodha; Frank W Sellke
Journal:  J Thorac Cardiovasc Surg       Date:  2016-11-16       Impact factor: 5.209

5.  Investigating the effects of resveratrol on chronically ischemic myocardium in a swine model of metabolic syndrome: a proteomics analysis.

Authors:  Ashraf A Sabe; Ahmed A Sadek; Nassrene Y Elmadhun; Rahul S Dalal; Michael P Robich; Cesario Bianchi; Frank W Sellke
Journal:  J Med Food       Date:  2015-01       Impact factor: 2.786

6.  Lipopolysaccharide (LPS)-induced septic shock causes profound changes in myocardial energy metabolites in pigs.

Authors:  Joaquin Lado-Abeal; Noelia Martinez-Sánchez; Jose Angel Cocho; Manuel Martín-Pastor; Isabel Castro-Piedras; M Luz Couce-Pico; Asish K Saha; Miguel López
Journal:  Metabolomics       Date:  2018-09-25       Impact factor: 4.290

7.  Differential effects of atorvastatin on autophagy in ischemic and nonischemic myocardium in Ossabaw swine with metabolic syndrome.

Authors:  Ashraf A Sabe; Nassrene Y Elmadhun; Ahmed A Sadek; Louis M Chu; Cesario Bianchi; Frank W Sellke
Journal:  J Thorac Cardiovasc Surg       Date:  2014-08-13       Impact factor: 5.209

8.  Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates.

Authors:  Julie A Mattison; Mingyi Wang; Michel Bernier; Jing Zhang; Sung-Soo Park; Stuart Maudsley; Steven S An; Lakshmi Santhanam; Bronwen Martin; Shakeela Faulkner; Christopher Morrell; Joseph A Baur; Leonid Peshkin; Danuta Sosnowska; Anna Csiszar; Richard L Herbert; Edward M Tilmont; Zoltan Ungvari; Kevin J Pearson; Edward G Lakatta; Rafael de Cabo
Journal:  Cell Metab       Date:  2014-05-29       Impact factor: 27.287

9.  Models for preclinical studies in aging-related disorders: One is not for all.

Authors:  Gaetano Santulli; Consuelo Borras; Jean Bousquet; Laura Calzà; Antonio Cano; Maddalena Illario; Claudio Franceschi; Giuseppe Liotta; Marcello Maggio; William D Molloy; Nunzia Montuori; Rónán O'Caoimh; Francesc Orfila; Amelia P Rauter; Aurelia Santoro; Guido Iaccarino
Journal:  Transl Med UniSa       Date:  2016-01-31

Review 10.  Challenges in Analyzing the Biological Effects of Resveratrol.

Authors:  Cihan Suleyman Erdogan; Ole Vang
Journal:  Nutrients       Date:  2016-06-09       Impact factor: 5.717
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