BACKGROUND: The relationship between fibroblast growth factor 23 (FGF23) and vitamin D production and catabolism post-renal transplantation has not been characterized. METHODS: Circulating creatinine, calcium, phosphorus, albumin, parathyroid hormone, FGF23, and 1,25(OH)2 vitamin D (calcitriol) values were obtained pre-transplantation, daily post-operatively for 5 days, and at 6 months post-transplantation in 44 patients aged 16.4 ± 0.4 years undergoing renal transplantation at UCLA from 1 August 2005 through to 30 April 2007. 25(OH) Vitamin D and 24,25(OH)2 vitamin D concentrations were obtained at baseline and on post-operative days 5 and 180, and urinary concentrations of creatinine, phosphorus, and FGF23 were measured on post-operative days 1, 3, 5, and 180. RESULTS: Circulating phosphate concentrations declined more rapidly and the fractional excretion of phosphorus was higher in the first week post-transplantation in subjects with higher FGF23 values. Fractional excretion of FGF23 was low at all time-points. Circulating 1,25(OH)2 vitamin D levels rose more rapidly and were consistently higher in patients with lower FGF23 values; however, 25(OH) vitamin D and 24,25(OH)2 vitamin D values were unrelated to FGF23 concentrations. CONCLUSIONS: Inhibition of renal 1α-hydroxylase, rather than stimulation of 24-hydroxylase, may primarily contribute to the relationship between FGF23 values and calcitriol. The rapid decline in FGF23 levels post-transplantation in our patient cohort was not mediated solely by the filtration of intact FGF23 by the new kidney.
BACKGROUND: The relationship between fibroblast growth factor 23 (FGF23) and vitamin D production and catabolism post-renal transplantation has not been characterized. METHODS: Circulating creatinine, calcium, phosphorus, albumin, parathyroid hormone, FGF23, and 1,25(OH)2 vitamin D (calcitriol) values were obtained pre-transplantation, daily post-operatively for 5 days, and at 6 months post-transplantation in 44 patients aged 16.4 ± 0.4 years undergoing renal transplantation at UCLA from 1 August 2005 through to 30 April 2007. 25(OH) Vitamin D and 24,25(OH)2 vitamin D concentrations were obtained at baseline and on post-operative days 5 and 180, and urinary concentrations of creatinine, phosphorus, and FGF23 were measured on post-operative days 1, 3, 5, and 180. RESULTS: Circulating phosphate concentrations declined more rapidly and the fractional excretion of phosphorus was higher in the first week post-transplantation in subjects with higher FGF23 values. Fractional excretion of FGF23 was low at all time-points. Circulating 1,25(OH)2 vitamin D levels rose more rapidly and were consistently higher in patients with lower FGF23 values; however, 25(OH) vitamin D and 24,25(OH)2 vitamin D values were unrelated to FGF23 concentrations. CONCLUSIONS: Inhibition of renal 1α-hydroxylase, rather than stimulation of 24-hydroxylase, may primarily contribute to the relationship between FGF23 values and calcitriol. The rapid decline in FGF23 levels post-transplantation in our patient cohort was not mediated solely by the filtration of intact FGF23 by the new kidney.
Authors: A I Sánchez Fructuoso; M L Maestro; N Calvo; V De La Orden; I Pérez Flores; M Vidaurreta; R Valero; C Fernández-Pérez; A Barrientos Journal: Transplant Proc Date: 2012-11 Impact factor: 1.066
Authors: Sangeeta Pande; Cynthia S Ritter; Marcos Rothstein; Karen Wiesen; John Vassiliadis; Rajiv Kumar; Susan C Schiavi; Eduardo Slatapolsky; Alex J Brown Journal: Nephron Physiol Date: 2006-05-10
Authors: W Reinhardt; H Bartelworth; F Jockenhövel; H Schmidt-Gayk; O Witzke; K Wagner; U W Heemann; D Reinwein; T Philipp; K Mann Journal: Nephrol Dial Transplant Date: 1998-02 Impact factor: 5.992
Authors: M Garabedian; C Silve; D Levy-Bentolila; A Bourdeau; A Ulmann; T M Nguyen; M Lieberherr; M Broyer; S Balsan Journal: Kidney Int Date: 1981-09 Impact factor: 10.612
Authors: Marjolein Bonthuis; Marco Busutti; Karlijn J van Stralen; Kitty J Jager; Sergey Baiko; Sevcan Bakkaloğlu; Nina Battelino; Maria Gaydarova; Bruno Gianoglio; Paloma Parvex; Clara Gomes; James G Heaf; Ludmila Podracka; Dafina Kuzmanovska; Maria S Molchanova; Tatiana E Pankratenko; Fotios Papachristou; György Reusz; Maria José Sanahuja; Rukshana Shroff; Jaap W Groothoff; Franz Schaefer; Enrico Verrina Journal: Clin J Am Soc Nephrol Date: 2015-02-20 Impact factor: 8.237
Authors: David E Leaf; Kirolos A Jacob; Anand Srivastava; Margaret E Chen; Marta Christov; Harald Jüppner; Venkata S Sabbisetti; Aline Martin; Myles Wolf; Sushrut S Waikar Journal: J Am Soc Nephrol Date: 2016-12-27 Impact factor: 10.121