| Literature DB >> 23850892 |
Ping-Yu Wang1, Yun-Xiao Sun, Shuai Zhang, Min Pang, Han-Han Zhang, Shu-Yan Gao, Can Zhang, Chang-Jun Lv, Shu-Yang Xie.
Abstract
MicroRNAs have tumor suppressive or oncogenic roles in carcinogenesis. This study aimed to investigate the mechanism of let-7c in suppressing lung cancer cell proliferation. First, let-7c was revealed to be able to inhibit lung adenocarcinoma cell proliferation significantly. TRIB2 was further demonstrated to be a novel target and negatively regulated by let-7c. As downstream signals of TRIB2, the activities of C/EBP-α and phosphorylated p38MAPK were increased obviously in let-7c-treated cells compared with controls. Our results demonstrate that, through regulating the expression of TRIB2 and its downstream factors, let-7c can effectively inhibit A549 cell proliferation in vitro and in vivo.Entities:
Keywords: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; ASO; C/EBP; CCAAT/enhancer-binding protein; Cell proliferation; Gene expression; HCC; Let-7c; Lung adenocarcinoma; MAPK; MTT; TRIB2 gene; antisense oligonucleotides; hepatocellular carcinoma; miRNAs; microRNAs; mitogen-activated protein kinase
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Year: 2013 PMID： 23850892 DOI： 10.1016/j.febslet.2013.07.004
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124