| Literature DB >> 23849384 |
Dhaval Thakkar1, Roohi Gupta, Kenneth Monson, Natalya Rapoport.
Abstract
The effect of ultrasound on the permeability of blood vessels to nano-emulsion droplets was investigated using excised mouse carotid arteries as model blood vessels. Perfluorocarbon nano-droplets were formed by perfluoro-15-crown-5-ether and stabilized by poly(ethylene oxide)-co-poly(DL-lactide) block co-polymer shells. Nano-droplet fluorescence was imparted by interaction with fluorescein isothiocyanate-dextran (molecular weight = 70,000 Da). The permeability of carotid arteries to nano-droplets was studied in the presence and absence of continuous wave or pulsed therapeutic 1-MHz ultrasound. The data indicated that the application of ultrasound resulted in permeabilization of the vascular wall to nano-droplets. The effect of continuous wave ultrasound was substantially stronger than that of pulsed ultrasound of the same total energy. No effect of blood vessel pre-treatment with ultrasound was observed. 2013 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reservedEntities:
Keywords: Extravasation; Nano-droplets; Nano-emulsions; Perfluorocarbon; Permeabilization; Ultrasound
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Year: 2013 PMID： 23849384 PMCID： PMC3777764 DOI： 10.1016/j.ultrasmedbio.2013.04.008
Source DB: PubMed Journal: Ultrasound Med Biol ISSN： 0301-5629 Impact factor: 2.998